Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
462-06-006 ISMRM Abstract

Deuterium Metabolic Imaging (DMI) in human breast – proof of concept and reproducibility

Primary: Contrast Mechanisms - Deuterium
Secondary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
462-06-006 · Breast MRI: Technical Developments · Tuesday, 12 May, 4:55 PM–5:50 PM · Digital Posters Row C
Keywords: Breast Cancer Deuterium Metabolic Imaging Deuterium MRSI
Accepted
Claudius S Mathy 1, Luka Stam2, Mark Gosselink2, Sonja Vliek3, Dimitri Welting2, Cezar Alborahal2, Michael Uder1, Tobias Bäuerle1,4, Armin M NAGEL1,5, Jannie Wijnen2,6, Dennis Klomp2,7
1Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
2Department of Radiology, Centre for Image Sciences, UMC Utrecht, Utrecht, Netherlands
3Department of Medical Oncology, UMC Utrecht, Utrecht, Netherlands
4Institute of Diagnostic and Interventional Radiology, University Medical Center of Johannes Gutenberg-University, Mainz, Germany
5Division of Medical Physics, German Cancer Research Center (DKFZ), Heidelberg, Germany
6Department of Pediatric Neuro-Oncology, Princes Máxima Center for Pediatric Oncology, Netherlands
7Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands
Presenting Author: Claudius S Mathy

Synopsis

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References

1. De Feyter, H. M.; Behar, K. L.; Corbin, Z. A.; Fulbright, R. K.; Brown, P. B.; McIntyre, S.; Nixon, T. W.; Rothman, D. L.; de Graaf, R. A. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Sci Adv 2018, 4 (8), eaat7314. DOI: 10.1126/sciadv.aat7314. [doi]
2. Lu, M.; Zhu, X.-H.; Zhang, Y.; Mateescu, G.; Chen, W. Quantitative assessment of brain glucose metabolic rates using in vivo deuterium magnetic resonance spectroscopy. J. Cereb. Blood Flow Metab. 2017, 37 (11), 3518–3530. DOI: 10.1177/0271678X17706444. [doi]
3. Hesse, F.; Somai, V.; Kreis, F.; Bulat, F.; Wright, A. J.; Brindle, K. M. Monitoring tumor cell death in murine tumor models using deuterium magnetic resonance spectroscopy and spectroscopic imaging. Proceedings of the National Academy of Sciences 2021, 118 (12), e2014631118. DOI: 10.1073/pnas.2014631118. [doi]
4. Katz-Brull, R.; Margalit, R.; Bendel, P.; Degani, H. Choline metabolism in breast cancer; 2 H-, 13 C-and 31 P-NMR studies of cells and tumors. Magnetic Resonance Materials in Physics, Biology and Medicine 1998, 6, 44–52.
5. Gursan, A.; Kahraman‐Agir, B.; Gosselink, M.; Welting, D.; Froeling, M.; Hoogduin, H.; Wiegers, E. C.; Prompers, J. J.; Klomp, D. W. Development of a Double Tuned 2H/31P Whole‐Body Birdcage Transmit Coil for 2H and 31P MR Applications From Head to Toe at 7 T. NMR Biomed. 2025, 38 (3), e5325. DOI: 10.1002/nbm.5325. [doi]
6. Froeling, M.; Prompers, J. J.; Klomp, D. W.; van der Velden, T. A. PCA denoising and Wiener deconvolution of 31P 3D CSI data to enhance effective SNR and improve point spread function. Magn. Reson. Med. 2021, 85 (6), 2992–3009. DOI: 10.1002/mrm.28654. [doi]
7. van den Wildenberg, L.; Gursan, A.; Seelen, L. W.; van der Velden, T. A.; Gosselink, M. W.; Froeling, M.; van der Kemp, W. J.; Klomp, D. W.; Prompers, J. J. In vivo phosphorus magnetic resonance spectroscopic imaging of the whole human liver at 7 T using a phosphorus whole‐body transmit coil and 16‐channel receive array: Repeatability and effects of principal component analysis‐based denoising. NMR Biomed. 2023, 36 (5), e4877. DOI: 10.1002/nbm.4877. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/462-06-006