Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-02-005 ISMRM Abstract

Uncovering hidden white matter changes using free water corrected DTI in a 3-month migraine clinical trial with fremanezumab

Primary: Diffusion - DWI/DTI/DKI
Secondary: Neuro - White Matter
663-02-005 · Diffusion: DWI/DTI/DKI · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row D
Keywords: Treatment Response Biomarkers Neuro Migraine Disorders Free-water DTI model
Accepted
Álvaro Planchuelo-Gómez 1,2, Alessandra Gallo1, Álvaro Sierra3,4, Yésica González-Osorio3,4, Ángel L Guerrero3,4,5, Lorenzo Pérez-Sánchez6, Raúl Moro6, Antonio Tristán-Vega1,2, Rodrigo de Luis García1,2, David García-Azorín5,7, Santiago Aja-Fernández1,2
1Imaging Processing Laboratory, UNIVERSIDAD DE VALLADOLID, Valladolid, Spain
2LPI-BIVa, Health Research Institute of Valladolid (IBioVALL), Valladolid, Spain
3Headache Unit, Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
4INCEVAL, Health Research Institute of Valladolid (IBioVALL), Valladolid, Spain
5Department of Medicine, UNIVERSIDAD DE VALLADOLID, Valladolid, Spain
6Department of Radiology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
7Department of Neurology, Hospital Universitario Río Hortega, Valladolid, Spain
Presenting Author: Álvaro Planchuelo-Gómez

Synopsis

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References

1. Rahimi R, Dolatshahi M, Abbasi-Feijani F, et al. Microstructural white matter alterations associated with migraine headaches: a systematic review of diffusion tensor imaging studies. Brain Imaging Behav. 2022;16(5):2375-2401. doi:10.1007/s11682-022-00690-1 [doi]
2. Steiner TJ, Stovner LJ, Vos T, Jensen R, Katsarava Z. Migraine is first cause of disability in under 50s: will health politicians now take notice? J Headache Pain. 2018;19(1):17. doi:10.1186/s10194-018-0846-2 [doi]
3. Metzler-Baddeley C, O’Sullivan MJ, Bells S, Pasternak O, Jones DK. How and how not to correct for CSF-contamination in diffusion MRI. Neuroimage. 2012;59(2):1394-1403. doi:10.1016/j.neuroimage.2011.08.043 [doi]
4. Andica C, Kamagata K, Hatano T, et al. MR Biomarkers of Degenerative Brain Disorders Derived From Diffusion Imaging. Journal of Magnetic Resonance Imaging. 2020;52(6):1620-1636. doi:10.1002/jmri.27019 [doi]
5. Correia MM, Henriques RN, Golub M, Winzeck S, Nunes RG. The trouble with free-water elimination using single-shell diffusion MRI data: A case study in ageing. Imaging Neuroscience. 2024;2:imag-2-00252. doi:10.1162/imag_a_00252 [doi]
6. Tristán-Vega A, París G, de Luis-García R, Aja-Fernández S. Accurate free-water estimation in white matter from fast diffusion MRI acquisitions using the spherical means technique. Magn Reson Med. 2022;87(2):1028-1035. doi:10.1002/mrm.28997 [doi]
7. Tournier JD, Smith R, Raffelt D, et al. MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation. Neuroimage. 2019;202:116137. doi:10.1016/j.neuroimage.2019.116137 [doi]
8. Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM. FSL. Neuroimage. 2012;62:782-790. doi:10.1016/j.neuroimage.2011.09.015 [doi]
9. Smith SM, Jenkinson M, Johansen-Berg H, et al. Tract-based Spatial Statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage. 2006;31(4):1487-1505. doi:10.1016/j.neuroimage.2006.02.024 [doi]
10. Oishi K, Zilles K, Amunts K, et al. Human brain white matter atlas: identification and assignment of commom anatomical structures in superficial white matter. Neuroimage. 2008;43(3):447-457. doi:10.1016/j.neuroimage.2008.07.009 [doi]
11. Lenth R V, Piaskowski J. emmeans: Estimated Marginal Means, aka Least-Squares Means. Preprint posted online 2025. https://rvlenth.github.io/emmeans/
12. Benjamini Y, Hochberg Y. Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society Series B (Methodological). 1995;57(1):289-300. doi:10.2307/2346101 [doi]
13. Griffa G, Palombo M, Yeffal A, Lee HH, Huang SY, Della-Maggiore V. Distinct cellular processes drive motor skill learning in the human brain. bioRxiv. Published online 2025. doi:10.1101/2025.09.22.677842 [doi]
14. Aja-Fernández S, de Luis-García R, Afzali M, Molendowska M, Pieciak T, Tristán-Vega A. Micro-structure diffusion scalar measures from reduced MRI acquisitions. PLoS One. 2020;15:1-25. doi:10.1371/journal.pone.0229526 [doi]
15. Aja-Fernández S, Pieciak T, Martín-Martín C, Planchuelo-Gómez Á, de Luis-García R, Tristán-Vega A. Moment-based representation of the diffusion inside the brain from reduced DMRI acquisitions: Generalized AMURA. Med Image Anal. 2022;77:102356. doi:10.1016/j.media.2022.102356 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/663-02-005