Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
365-03-006 ISMRM Abstract

Hybrid Diffusion of Cervical-Thoracic Pediatric Spinal Cord: Normative Analysis of NODDI, DKI, and DTI Metrics

Primary: Diffusion - DWI/DTI/DKI
Secondary: Pediatrics - Normal Development
365-03-006 · Body Diffusion MRI Methods · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row F
Keywords: DWI/DTI/DKI Neurite orientation dispersion and density imaging Pediatric spinal cord Hybrid Diffusion Imaging Tissue-resolved normative references
Accepted
Zahra Sadeghi Adl1, Devon Middleton2,3,4, Laura Krisa3,4,5,6, Sara Naghizadehkashani1, Mahdi Alizadeh2,3, Slimane Tounekti7,8, Scott H Faro1, Adam Flanders1, Julien Cohen-Adad9,10,11,12,13,14,15,16, Feroze Mohamed 2,3,4
1Department of Radiology, Jefferson Integrated Magnetic Resonance Imaging Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
2Thomas Jefferson University, Philadelphia, United States of America
3Radiology, Thomas Jefferson University, Philadelphia, United States of America
4Jefferson Integrated Magnetic Resonance Imaging Center, Department of Radiology, Thomas Jefferson University, Philadelphia, United States of America
5Occupational Therapy, Thomas Jefferson University, Philadelphia, United States of America
6Department of Occupational Therapy, Thomas Jefferson University, Philadelphia, United States of America
7Radiology, University of Pennsylvania, Philadelphia, United States of America
8Center for Advanced Metabolic Imaging in Precision Medicine, Philadelphia, United States of America
9NeuroPoly Lab, Montreal, Canada
10Mila - Quebec AI Institute, Montreal, Canada
11Functional Neuroimaging Unit, Montreal, Canada
12Centre de Recherche du CHU Sainte-Justine, Montreal, Canada
13NeuroPoly Lab, Institute of Biomedical Engineering,, Polytechnique Montréal, Montréal, Canada
14CHU Sainte-Justine Research Center, Montréal, Canada, Canada
15Centre de recherche du CHU Sainte-Justine, Montréal, Canada
16NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada
Presenting Author: Feroze Mohamed

Synopsis

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References

1. 1. Stroman, P.W., et al., The current state-of-the-art of spinal cord imaging: methods. Neuroimage, 2014. 84: p. 1070-1081. DOI: 10.1016/j.neuroimage.2013.04.124 · PMID: 23685159. [doi] [pmid]
2. 2. Ellingson, B., et al., Diffusion tensor MR imaging of the neurologically intact human spinal cord. American Journal of Neuroradiology, 2008. 29(7): p. 1279-1284. DOI: 10.3174/ajnr.A1064 · PMID: 18417607. [doi] [pmid]
3. 3. Chagawa, K., et al., Normal values of diffusion tensor magnetic resonance imaging parameters in the cervical spinal cord. Asian spine journal, 2015. 9(4): p. 541. DOI: 10.4184/asj.2015.9.4.541 · PMID: 26240712. [doi] [pmid]
4. 4. Grussu, F., et al., Neurite orientation dispersion and density imaging of the healthy cervical spinal cord in vivo. Neuroimage, 2015. 111: p. 590-601. DOI: 10.1016/j.neuroimage.2015.01.045 · PMID: 25652391. [doi] [pmid]
5. 5. Conklin, C.J., et al., Spatially selective 2D RF inner field of view (iFOV) diffusion kurtosis imaging (DKI) of the pediatric spinal cord. NeuroImage: Clinical, 2016. 11: p. 61-67. DOI: 10.1016/j.nicl.2016.01.009 · PMID: 26909329. [doi] [pmid]
6. 6. Panara, V., et al., Spinal cord microstructure integrating phase-sensitive inversion recovery and diffusional kurtosis imaging. Neuroradiology, 2017. 59(8): p. 819-827. DOI: 10.1007/s00234-017-1864-5 · PMID: 28676888. [doi] [pmid]
7. 7. Shahrampour, S., et al., Atlas-based quantification of DTI measures in a typically developing pediatric spinal cord. American Journal of Neuroradiology, 2021. 42(9): p. 1727-1734. DOI: 10.3174/ajnr.A7221 · PMID: 34326104. [doi] [pmid]
8. 8. Wu, Y.-C. and A.L. Alexander, Hybrid diffusion imaging. NeuroImage, 2007. 36(3): p. 617-629. DOI: 10.1016/j.neuroimage.2007.02.050 · PMID: 17481920. [doi] [pmid]
9. 9. De Leener, B., et al., SCT: Spinal Cord Toolbox, an open-source software for processing spinal cord MRI data. Neuroimage, 2017. 145: p. 24-43. DOI: 10.1016/j.neuroimage.2016.10.009 · PMID: 27720818. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/365-03-006