Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-03-010 ISMRM Abstract

Quantifying glymphatic-relevant fluid and detecting its mobility with extended-echo-range multi-echo GRE (QUTE) at 7T

Primary: Neuro - Neurofluids
Secondary: Acquisition & Reconstruction - Quantitative Imaging: relaxometry, multi-parametric, MR Fingerprinting, and synthetic MRI
663-03-010 · Glymphatic System Imaging: From Neurofluid Transport to Neurodegeneration · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row D
Keywords: Cerebrospinal fluid Glymphatic transport T2star relaxometry NNLS QUTE
Accepted
Ana-Maria Oros-Peusquens 1, Seonyeong Shin1,2, N. Jon Shah1,2,3,4,5
1Institute of Neuroscience and Medicine 4, INM-4, Forschungszentrum Jülich, Jülich, Germany
2RWTH Aachen University, Aachen, Germany
3Institute of Neuroscience and Medicine 11, INM-11, JARA, Forschungszentrum Jülich, Germany
4Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany
5Aachen, JARA - BRAIN - Translational Medicine, Aachen, Germany
Presenting Author: Ana-Maria Oros-Peusquens

Synopsis

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References

1. Xie L. et al. Sleep drives metabolite clearance from the adult brain. Science, 2013.
2. Benveniste H. et al. The glymphatic system and waste clearance with anaesthesia. Annu Rev Biomed Eng, 2019.
3. Mestre H. et al. Aquaporin‑4 dependent glymphatic solute transport. J Neurosci/PNAS, 2018–2020 (reviews).
4. Iliff J.J., Nedergaard M. Brain’s glymphatic system. Nat Rev Neurosci, 2013–2022 (overviews).
5. Hirschler L., van Osch M., et al. Region‑specific drivers of CSF mobility measured with MRI in humans (T2‑prep with motion‑sensitizing gradients + long‑TE TSE). Nat Neurosci, 2025. doi:10.1038/s41593-025-02073-3 [doi]
6. Wright K. et al. Diffusion MRI of CSF dynamics (ultra‑long TE, CSF‑selective). NMR in Biomedicine, 2024.
7. ISMRM proceedings: high‑resolution long‑TE TSE with velocity/motion encoding for CSF mobility mapping (2019–2024).
8. Weigel M., Hennig J. Hyperecho/variable‑flip‑angle TSE physics enabling long‑TE readouts. MRM, 2006.
9. Provencher S.W. CONTIN: constrained regularization for Laplace inversions. Comput Phys Commun, 1982.
10. Whittall K.P., MacKay A.L. Quantitative interpretation of NMR relaxation data using NNLS spectra. J Magn Reson, 1989.
11. MacKay A.L. et al. Multi‑component T2 relaxometry and myelin water. Magn Reson Med/NeuroImage, 1994–2012 (reviews).
12. Chapter: Analysis of NMR relaxation data (linear inverse with smoothness penalties). Prog NMR Spectrosc, 1996.
13. Shin S, Oros‑Peusquens A‑M, Yun SD, Farrher E, Shah NJ. Development of an echo‑shifted, multi‑echo, gradient‑echo sequence for T2* quantification of slow‑relaxing water pools. Magn Reson Med. 2025; 94(5): 2057-2070
14. Oros-Peusquens, A. M., Loução, R., Abbas, Z. et al. A Single-Scan, Rapid Whole-Brain Protocol for Quantitative Water Content Mapping With Neurobiological Implications. Frontiers in neurology, 10, 1333.
15. Liu, T., Liu, J., de Rochefort, L., Spincemaille, P., Khalidov, I., Ledoux, J. R., & Wang, Y. (2011). Morphology enabled dipole inversion (MEDI) from a single-angle acquisition: comparison with COSMOS in human brain imaging. Magnetic resonance in medicine, 66(3), 777–783.
16. Song, J. E., Shin, J., Lee, H., Lee, H. J., Moon, W. J., & Kim, D. H. (2020). Blind Source Separation for Myelin Water Fraction Mapping Using Multi-Echo Gradient Echo Imaging. IEEE transactions on medical imaging, 39(6), 2235–2245
17. Courtney, Y., & Lehtinen, M. K. (2025). Apocrine secretion by the choroid plexus. Fluids and barriers of the CNS, 22(1), 75.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/663-03-010