Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
363-04-012 ISMRM Abstract

Longitudinal Assessment of Brain Iron Content after Neoadjuvant Chemotherapy in Breast Cancer using QSM

Primary: Neuro - Gray Matter
Secondary: Neuro - Other Neurodegeneration
363-04-012 · From Iron to Intelligence: Quantitative Imaging and AI in Brain Disorders · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row D
Keywords: Cognitive impairment Breast cancer Quantitative Susceptibility Mapping (QSM) Brain IRON
Accepted
菁 张 1, Yong Tan1,2,3, Daihong Liu1,3,4,5,6, Jiuquan Zhang3,4,6, Yanglei Wu7, Ting Yin8,9
1Department of Radiology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, ChongQing, China
2Chongqing University Cancer Hospital, Chongqing, China
3Department of Radiology, Chongqing University Cancer Hospital, Chongqing, China
4Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, ChongQing, China
5Department of Radiology Chongqing University Cancer Hospital, Chongqing, chongqing, China
6Department of Radiology, Chongqing University Cancer Hospital, Chongqing, China
7Department of Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany
8MR Collaborations, Siemens Healthineers Ltd., Shanghai, China
9MR Collaborations, Siemens Healthineers Ltd.Chengdu, China
Presenting Author: 菁 张

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. 1. Pondé NF, Zardavas D, Piccart M. Progress in adjuvant systemic therapy for breast cancer. Nat Rev Clin Oncol 2019;16(1):27-44. doi: 10.1038/s41571-018-0089-9 [doi]
2. 2. Feng Y, Zhang XD, Zheng G, Zhang LJ. Chemotherapy-induced brain changes in breast cancer survivors: evaluation with multimodality magnetic resonance imaging. Brain Imaging Behav 2019;13(6):1799-1814. doi: 10.1007/s11682-019-00074-y [doi]
3. 3. Brown T, Sykes D, Allen AR. Implications of Breast Cancer Chemotherapy-Induced Inflammation on the Gut, Liver, and Central Nervous System. Biomedicines 2021;9(2). doi: 10.3390/biomedicines9020189 [doi]
4. 4. Masaldan S, Bush AI, Devos D, Rolland AS, Moreau C. Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration. Free Radic Biol Med 2019;133:221-233. doi: 10.1016/j.freeradbiomed.2018.09.033 [doi]
5. 5. Urrutia P, Aguirre P, Esparza A, Tapia V, Mena N, Arredondo M, González-Billault C, Núñez MJJon. Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells. 2013;126(4):541-549. doi: 10.1111/jnc.12244 [doi]
6. 6. Barcellini W, Zaninoni A, Gregorini A, Soverini G, Duca L, Fattizzo B, Giannotta J, Pedrotti P, Vercellati C, Marcello A, Fermo E, Bianchi P, Cappellini MJBjoh. Iron overload in congenital haemolytic anaemias: role of hepcidin and cytokines and predictive value of ferritin and transferrin saturation. 2019;185(3):523-531. doi: 10.1111/bjh.15811 [doi]
7. 7. Bilgic B, Langkammer C, Marques JP, Meineke J, Milovic C, Schweser F. QSM reconstruction challenge 2.0: Design and report of results. Magn Reson Med 2021;86(3):1241-1255. doi: 10.1002/mrm.28754 [doi]
8. 8. Qian Z, Ke Y. Brain iron transport. Biological reviews of the Cambridge Philosophical Society 2019;94(5):1672-1684. doi: 10.1111/brv.12521 [doi]
9. 9. Ji J, Sun CL, Cohen HJ, Synold T, Muss H, Sedrak MS. Inflammation and Clinical Decline After Adjuvant Chemotherapy in Older Adults With Breast Cancer: Results From the Hurria Older Patients Prospective Study. J Clin Oncol 2023;41(2):307-315. doi: 10.1200/jco.22.01217 [doi]
10. 10. Jáuregui-Lobera I. Iron deficiency and cognitive functions. Neuropsychiatr Dis Treat 2014;10:2087-2095. doi: 10.2147/ndt.S72491 [doi]
11. 11. Moon CM, Jeong GW. Functional neuroanatomy on the working memory under emotional distraction in patients with generalized anxiety disorder. Psychiatry Clin Neurosci 2015;69(10):609-619. doi: 10.1111/pcn.12295 [doi]
12. 12. Al-Otaibi M, Lessard-Beaudoin M, Castellano CA, Gris D, Cunnane SC, Graham RK. Volumetric MRI demonstrates atrophy of the olfactory cortex in AD. Curr Alzheimer Res 2020;17(10):904-915. doi: 10.2174/1567205017666201215120909 [doi]
13. 13. Qian Z, Ke YJMrr. Hepcidin and its therapeutic potential in neurodegenerative disorders. 2020;40(2):633-653. doi: 10.1002/med.21631 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/363-04-012