Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
570-08-223 ISMRM Abstract

Neurometabolic similarity matrix to study metabolic connectivity in chronic hepatic encephalopathy: a preliminary study

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Preclinical Animal & in vitro MR - Small Animals
570-08-223 · Preclinical · Wednesday, 13 May, 4:00 PM–4:55 PM · Traditional Posters | Exhibition Hall
Keywords: Metabolic imaging 1H-MRSI Chronic Hepatic Encephalopathy BDL rat Metabolic Similarity Matrix
Accepted
Thi Ngoc Anh Dinh 1,2, Gianna Nossa1,2, Tan Toi Phan1,2, Federico Lucchetti3, Valerie McLin4, Paul Klauser3,5, Cristina Cudalbu1,2
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland
2CIBM Pre-Clinical Imaging EPFL, Metabolic Imaging Section, EPFL, Lausanne, Switzerland
3Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
4Swiss Pediatric Liver Center, Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland, Switzerland
5Division of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
Presenting Author: Thi Ngoc Anh Dinh

Synopsis

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References

1. Vilstrup, Hendrik, et al. "Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver." Hepatology 60.2 (2014): 715-735. doi: 10.1002/hep.27210 [doi]
2. Häussinger, Dieter, et al. "Hepatic encephalopathy." Nature Reviews Disease Primers 8.1 (2022): 43. https://doi.org/10.1038/s41572-022-00366-6 [doi]
3. Sepanlou, Sadaf G., et al. "The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017." The Lancet gastroenterology & hepatology 5.3 (2020): 245-266. https://doi.org/10.1016/S2468-1253(19)30349-8 [doi]
4. Simicic, Dunja, et al. "Differential metabolic and cellular brain regional susceptibility in adult rats with chronic liver disease." arXiv preprint arXiv:2503.20073 (2025). https://doi.org/10.48550/arXiv.2503.20073 [doi]
5. Rackayova, Veronika, et al. "Longitudinal osmotic and neurometabolic changes in young rats with chronic cholestatic liver disease." Scientific reports 10.1 (2020): 7536. https://doi.org/10.1038/s41598-020-64416-3 [doi]
6. Braissant, Olivier, et al. "Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy." Journal of hepatology 71.3 (2019): 505-515. https://doi.org/10.1016/j.jhep.2019.05.022 [doi]
7. Simicic, Dunja, et al. "Fast High‐Resolution Metabolite Mapping in the rat Brain Using 1H‐FID‐MRSI at 14.1 T." NMR in Biomedicine 38.2 (2025): e5304. https://doi.org/10.1002/nbm.5304 [doi]
8. https://www.epfl.ch/labs/mrs4brain/ressources/mrs4brain-toolbox/
9. Lucchetti, Federico, et al. "Constructing the Human Brain Metabolic Connectome Using MR Spectroscopic Imaging: Insights into Biochemical Organization, Cytoarchitectonic Similarity and Gene Co-expression Networks." bioRxiv (2025): 2025-03. https://doi.org/10.1101/2025.03.10.642332 [doi]
10. Radiske, Andressa, et al. "Theta-encoded information flow from dorsal CA1 to prelimbic cortex drives memory reconsolidation." iScience (2025). https://doi.org/10.1016/j.isci.2025.112821 [doi]
11. Jao, Tun, et al. "Functional brain network changes associated with clinical and biochemical measures of the severity of hepatic encephalopathy." Neuroimage 122 (2015): 332-344. https://doi.org/10.1016/j.neuroimage.2015.07.068 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/570-08-223