Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-06-005 ISMRM Abstract

Higher Body Mass Index Associated with More Efficient Functional Brain Networks in Midlife World Trade Center Responders

Primary: Neuro - Dementia
Secondary: Brain Function and fMRI - Functional Connectivity
460-06-005 · Imaging the Brain’s Microenvironment: From Glymphatics to Cognition · Tuesday, 12 May, 4:55 PM–5:50 PM · Digital Posters Row A
Keywords: Cognitive impairment Functional Brain Network BMI
Accepted
Xinlan Zhang1, Jia Ying2,3, Tianyun Zhao2,3, Sean A Clouston4,5, Benjamin Luft6, Chuan Huang1
1Radiology & Imaging Sciences, Emory University, Atlanta, United States of America
2Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, United States of America
3Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, United States of America
4Program in Public Health, State University of New York at Stony Brook, Stony Brook, United States of America
5Department of Family, Population, and Preventive Medicine, State University of New York at Stony Brook, Stony Brook, United States of America
6Department of Medicine, Division on Infectious Diseases, State University of New York at Stony Brook, Stony Brook, United States of America
Presenting Author: Sixuan Guo

Synopsis

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References

1. Nguyen, J. C. D., Killcross, A. S., & Jenkins, T. A. (2014). Obesity and cognitive decline: Role of inflammation and vascular changes. Frontiers in Neuroscience, 8, 375.
2. Crane, B. M., Nichols, E., Carlson, M. C., Deal, J. A., & Gross, A. L. (2023). Body Mass Index and Cognition: Associations Across Mid- to Late Life and Gender Differences. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 78(6), 988–996.
3. Fitzpatrick, A. L., Kuller, L. H., Lopez, O. L., Diehr, P., O’Meara, E. S., Longstreth, W. T., & Luchsinger, J. A. (2009). Midlife and late-life obesity and the risk of dementia: Cardiovascular health study. Archives of Neurology, 66(3), 336–342.
4. Natale, G., Zhang, Y., Hanes, D. W., & Clouston, S. A. (2023). Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality. American Journal of Alzheimer’s Disease and Other Dementias, 38, 15333175221111658.
5. Clouston, S. A. P., Hall, C. B., Kritikos, M., Bennett, D., DeKosky, S., Edwards, J., Finch, C., Kreisl, W., Mielke, M., Peskind, E. R., Raskind, M., Richards, M., Sloan, R. P., Spiro, A., Vasdev, N., Brackbill, R., Farfel, M., Horton, M., Lowe, S., … Luft, B. J. (2022). Cognitive impairment and World Trade Centre-related exposures. Nature Reviews. Neurology, 18(2), 103–116.
6. Clouston, S. A. P., Kotov, R., Pietrzak, R. H., Luft, B. J., Gonzalez, A., Richards, M., Ruggero, C. J., Spiro, A., & Bromet, E. J. (2016). Cognitive impairment among World Trade Center responders: Long-term implications of re-experiencing the 9/11 terrorist attacks. Alzheimer’s & Dementia : Diagnosis, Assessment & Disease Monitoring, 4, 67–75.
7. Clouston, S. A. P., Mann, F. D., Meliker, J., Kuan, P.-F., Kotov, R., Richmond, L. L., Babalola, T., Kritikos, M., Yang, Y., Carr, M. A., & Luft, B. J. (2024). Incidence of Dementia Before Age 65 Years Among World Trade Center Attack Responders. JAMA Network Open, 7(6), e2416504.
8. Boppre, G., Nunes, J. P. R., Fernandes, D. G., Carlos, B. J. de C. S. e R., Barros, J. M. N., de Freitas, A. T. M., dos Santos, J. A. R., & Zacca, R. (2025). Muscle, Fat, Bone, and Lungs: Unlocking the Fitness and Health Equation of Firefighters in Porto, Portugal. Life, 15(3), Article 3.
9. McKinney, Z. J., Bovard, R. S., Starchook-Moore, M. N., Ronneberg, K., Xi, M., Bredeson, D. M., Schwartz, E. C., Thelen, S. L., Nash, T. L., Dickinson, M., McDonough, T., Hirdman, K., & Pronk, N. P. (2021). Cardiorespiratory Fitness of Firefighters. Journal of Occupational and Environmental Medicine, 63(1), 57–63.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/460-06-005