Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
364-01-014 ISMRM Abstract

Integrated Macro- and Microstructural Gradients Reveal Complementary Contributions to Cortical Functional Hierarchy

Primary: Brain Function and fMRI - Functional Connectivity
Secondary: Analysis Methods - Data Processing
364-01-014 · fMRI: Analyses · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row E
Keywords: Diffusion-weighted MRI Structural covariance network Structure function coupling Structural-Functioanl Connectivity Cerebral cortical morphology
Accepted
Paween Wongkornchaovalit 1,2, Tianyong Xu3, Jingcheng Wang3, Jintao Wei4, Yahong Chen3, Junye Yao5, Bingchen Shao3,6, Lu Han7, Hongjian HE3,8
1International College, Zhejiang University, Hangzhou, China
2College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China
3School of Physics, Zhejiang University, Hangzhou, China
4College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China
5Clinical & Technical Support, Philips Healthcare, Guangzhou, China
6Zhejiang University, Hangzhou, China
7Philips Healthcare, Guangzhou, China
8State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China
Presenting Author: Paween Wongkornchaovalit

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Alexander-Bloch A, Raznahan A, Bullmore E, Giedd J. The Convergence of Maturational Change and Structural Covariance in Human Cortical Networks. J Neurosci. 2013 Feb 13;33(7):2889–99. DOI: 10.1523/JNEUROSCI.3554-12.2013 [doi]
2. Alexander-Bloch A, Giedd JN, Bullmore E. Imaging structural co-variance between human brain regions. Nat Rev Neurosci. 2013 May;14(5):322–36. DOI: 10.1038/nrn3465 [doi]
3. Carmon J, Heege J, Necus JH, Owen TW, Pipa G, Kaiser M, et al. Reliability and comparability of human brain structural covariance networks. NeuroImage. 2020 Oct;220:117104. https://doi.org/10.1016/j.neuroimage.2020.117104 [doi]
4. Bihan DL. Molecular diffusion, tissue microdynamics and microstructure. NMR in Biomedicine. 1995 Nov;8(7):375–86. DOI: 10.1002/nbm.1940080711 [doi]
5. Le Bihan D. Looking into the functional architecture of the brain with diffusion MRI. Nat Rev Neurosci. 2003 Jun;4(6):469–80. DOI: 10.1038/nrn1119 [doi]
6. Wu X, Palaniyappan L, Yu G, Zhang K, Seidlitz J, Liu Z, et al. Morphometric dis-similarity between cortical and subcortical areas underlies cognitive function and psychiatric symptomatology: a preadolescence study from ABCD. Mol Psychiatry. 2023 Mar;28(3):1146–58. DOI: 10.1038/s41380-022-01896-x [doi]
7. Sadikov A, Choi HL, Xiao J, Cai LT, Mukherjee P. Mapping the microstructure of human cerebral cortex in vivo with diffusion MRI. Commun Biol. 2025 Jul 22;8(1):1088. DOI: 10.1038/s42003-025-08523-9 [doi]
8. Sadikov A, Choi HL, Cai LT, Mukherjee P. Estimating Brain Similarity Networks With Diffusion MRI. Human Brain Mapping. 2025 Aug;46(11):e70313. DOI: 10.1002/hbm.70313 [doi]
9. Pareek V, Rallabandi VS, Roy PK. A Correlational Study between Microstructural White Matter Properties and Macrostructural Gray Matter Volume Across Normal Ageing: Conjoint DTI and VBM Analysis. Magn Reson Insights. 2018 Jan;11. DOI: 10.1177/1178623X18799926 [doi]
10. Uddin MdN, Figley TD, Solar KG, Shatil AS, Figley CR. Comparisons between multi-component myelin water fraction, T1w/T2w ratio, and diffusion tensor imaging measures in healthy human brain structures. Sci Rep. 2019 Feb 21;9(1):2500. DOI: 10.1038/s41598-019-39199-x [doi]
11. Tian Q, Fan Q, Witzel T, Polackal MN, Ohringer NA, Ngamsombat C, et al. Comprehensive diffusion MRI dataset for in vivo human brain microstructure mapping using 300 mT/m gradients. Sci Data. 2022 Jan 18;9(1):7. DOI: 10.1038/s41597-021-01092-6 [doi]
12. Fischl B. FreeSurfer. NeuroImage. 2012 Aug;62(2):774–81. DOI: 10.1016/j.neuroimage.2012.01.021 [doi]
13. Schaer M, Cuadra MB, Schmansky N, Fischl B, Thiran JP, Eliez S. How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index. JoVE. 2012 Jan 2;(59):3417. DOI: 10.3791/3417 [doi]
14. Garyfallidis E, Brett M, Amirbekian B, Rokem A, Van Der Walt S, Descoteaux M, et al. Dipy, a library for the analysis of diffusion MRI data. Front Neuroinform [Internet]. 2014 Feb 21 [cited 2025 Oct 27];8. Available from: http://journal.frontiersin.org/article/10.3389/fninf.2014.00008/abstract
15. Zhang H, Schneider T, Wheeler-Kingshott CA, Alexander DC. NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. Neuroimage. 2012 Jul 16;61(4):1000–16. DOI: 10.1016/j.neuroimage.2012.03.072 [doi]
16. Du J, DiNicola LM, Angeli PA, Saadon-Grosman N, Sun W, Kaiser S, et al. Organization of the human cerebral cortex estimated within individuals: networks, global topography, and function. Journal of Neurophysiology. 2024 Jun 1;131(6):1014–82. DOI: 10.1152/jn.00308.2023 [doi]
17. Vos De Wael R, Benkarim O, Paquola C, Lariviere S, Royer J, Tavakol S, et al. BrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets. Commun Biol. 2020 Mar 5;3(1):103. DOI: 10.1038/s42003-020-0794-7 [doi]
18. Margulies DS, Ghosh SS, Goulas A, Falkiewicz M, Huntenburg JM, Langs G, et al. Situating the default-mode network along a principal gradient of macroscale cortical organization. Proc Natl Acad Sci USA. 2016 Nov;113(44):12574–9. DOI: 10.1073/pnas.1608282113 [doi]
19. Paquola C, Vos De Wael R, Wagstyl K, Bethlehem RAI, Hong SJ, Seidlitz J, et al. Microstructural and functional gradients are increasingly dissociated in transmodal cortices. Kennedy H, editor. PLoS Biol. 2019 May 20;17(5):e3000284. DOI: 10.1371/journal.pbio.3000284 [doi]
20. Vázquez-Rodríguez B, Suárez LE, Markello RD, Shafiei G, Paquola C, Hagmann P, et al. Gradients of structure-function tethering across neocortex. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21219–27. DOI: 10.1073/pnas.1903403116 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/364-01-014