Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
331-03-014 / 331-03-014 ISMRM Abstract

Inflammation-related alterations in brain network segregation and integration predict cognitive outcomes after mild TBI

Primary: Neuro - Traumatic Brain Injury
Secondary: Brain Function and fMRI - fMRI Analysis
331-03-014 · Clinical Applications in Psychiatry and Neurology · Monday, 11 May, 4:10 PM–5:36 PM · Roof Terrace
331-03-014 · Clinical Applications in Psychiatry and Neurology · Monday, 11 May, 4:10 PM–5:36 PM · Roof Terrace
Keywords: fMRI (resting state) Mild Traumatic Brain Injury Nested-spectral partition Segregation Integration
Accepted
Ruiting Zhu 1,2, XINGPU QUAN1, Gengchen Ye1, Feng Liu3, Lu Zhang1, Jingling Qiang4, Ronghui Wang5, Yuzhe Huang6, Ming Zhang1, Xuan Niu1
1The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
2School of Future Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China
3Ankang Central Hospital, Ankang, China
4the Affiliated Hospital of Yanan University, Yanan, China
5Department of Neurosurgery, the Affiliated Hospital of Yanan University, Yanan, China
6Health Science Center, Xi’an Jiaotong Universtiy Health Science Center, Xian, China
Presenting Author: Ruiting Zhu

Synopsis

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References

1. Niu X, Bai L, Sun Y, et al. Disruption of periaqueductal grey-default mode network functional connectivity predicts persistent post-traumatic headache in mild traumatic brain injury. J Neurol Neurosurg Psychiatry 2019;90(3):326-32. doi: 10.1136/jnnp-2018-318886 [doi]
2. Mavroudis I, Ciobica A, Bejenariu AC, et al. Cognitive Impairment following Mild Traumatic Brain Injury (mTBI): A Review. Medicina 2024;60(3):380. doi: 10.3390/medicina60030380 [doi]
3. Calderone A, Latella D, Cardile D, et al. The Role of Neuroinflammation in Shaping Neuroplasticity and Recovery Outcomes Following Traumatic Brain Injury: A Systematic Review. Int J Mol Sci 2024;25(21) doi: 10.3390/ijms252111708 [doi]
4. Boroda E, Armstrong M, Gilmore CS, et al. Network topology changes in chronic mild traumatic brain injury (mTBI). Neuroimage Clin 2021;31:102691. doi: 10.1016/j.nicl.2021.102691 [doi]
5. Woodcock T, Morganti-Kossmann MC. The role of markers of inflammation in traumatic brain injury. Front Neurol 2013;4:18. doi: 10.3389/fneur.2013.00018 [doi]
6. Kann O, Almouhanna F, Chausse B. Interferon γ: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration. Trends Neurosci 2022;45(12):913-27. doi: 10.1016/j.tins.2022.10.007 [doi]
7. Leskinen S, Mehta NH, Shah HA, et al. Functional Connectivity Changes in Traumatic Brain Injury: A Systematic Review and Coordinate-Based Meta-Analysis of fMRI Studies. Neurology 2025;105(9):e214298. doi: 10.1212/wnl.0000000000214298 [doi]
8. Hou W, Sours Rhodes C, Jiang L, et al. Dynamic Functional Network Analysis in Mild Traumatic Brain Injury. Brain Connect 2019;9(6):475-87. doi: 10.1089/brain.2018.0629 [doi]
9. Sharp DJ, Scott G, Leech R. Network dysfunction after traumatic brain injury. Nat Rev Neurol 2014;10(3):156-66. doi: 10.1038/nrneurol.2014.15 [doi]
10. Simon DW, McGeachy MJ, Bayır H, et al. The far-reaching scope of neuroinflammation after traumatic brain injury. Nat Rev Neurol 2017;13(3):171-91. doi: 10.1038/nrneurol.2017.13 [doi]

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http://echo.ismrm.org/p/ISMRM2026/331-03-014