Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-02-013 ISMRM Abstract

Increased Extracellular Free-Water Fraction Exhibits Spatial Alignment with Neurotransmitter Systems in Parkinson’s Disease

Primary: Neuro - Parkinson's Disease
Secondary: Neuro - Gray Matter
369-02-013 · Imaging Parkinson’s Disease: Multimodal Biomarkers of Progression and Phenotype · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row J
Keywords: Parkinson's Disease Diffusion Tensor Imaging Free-water DTI model Diffusion Microstructure Neurochemistry
Accepted
Yang Zhao1, Aocai Yang1,2, Yufan Chen1, Tao Gong3, Xiuzheng Yue 4,5,6, guangbin wang1
1Department of Radiograpy, Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China
2China-Japan Friendship Hospital, Beijing, China
3Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250022, China
4Clinical and Technical Support, Philips Healthcare (Beijing), Beijing, China
5Medical Big Data Research Center, Medical Innovation Research Division, Chinese PLA General Hospital, Beijing, China
6Chinese PLA Medical School, Chinese PLA General Hospital, Beijing, China
Presenting Author: Xiuzheng Yue

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Morris HR, Spillantini MG, Sue CM, Williams-Gray CH. The pathogenesis of Parkinson’s disease. The Lancet. 2024;403(10423):293-304. doi:10.1016/S0140-6736(23)01478-2 [doi]
2. Sumra V, Hadian M, Dilliott AA, et al. Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration. J Neurol. 2025;272(7):478. doi:10.1007/s00415-025-13201-1 [doi]
3. Hansen JY, Shafiei G, Markello RD, et al. Mapping neurotransmitter systems to the structural and functional organization of the human neocortex. Nat Neurosci. 2022;25(11):1569-1581. doi:10.1038/s41593-022-01186-3 [doi]
4. Nagai Y, Fujimura T, Uchida W, et al. Gray matter microstructure alterations with excess extra-cellular free water contribute to cognitive dysfunction in bipolar disorder: A comparative analysis with white matter pathology. NeuroImage. 2025;317:121342. doi:10.1016/j.neuroimage.2025.121342 [doi]
5. Dukart J, Holiga S, Rullmann M, et al. JuSpace : A tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps. Hum Brain Mapp. 2021;42(3):555-566. doi:10.1002/hbm.25244 [doi]
6. Rascol O, Fabbri M, Poewe W. Amantadine in the treatment of Parkinson’s disease and other movement disorders. Lancet Neurol. 2021;20(12):1048-1056. doi:10.1016/S1474-4422(21)00249-0 [doi]
7. Zhuang Y, Xu P, Mao C, et al. Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell. 2021;184(4):931-942.e18. doi:10.1016/j.cell.2021.01.027 [doi]
8. Onofrj M, Gilbert GJ. GABA and hallucinations in Parkinson disease: Who is that sitting on my chair? Neurology. 2018;91(7):293-294. doi:10.1212/WNL.0000000000005985 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-02-013