Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
468-02-008 ISMRM Abstract

Neuroanatomical Subtypes in Type 2 Diabetes Mellitus Reveal Cortical Heterogeneity with Cognitive and Metabolic Dysfunction

Primary: Neuro - Gray Matter
Secondary: Neuro - Other Neurodegeneration
468-02-008 · Type 2 Diabetes · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row I
Keywords: Metabolism Cognitive impairment Type 2 diabetes mellitus Heterogeneity Structural T1 MRI
Accepted
Xiaomei Yue 1, Shijun Qiu2
1Guangzhou university of chinese medicine, Guangzhou, China
2The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Presenting Author: Xiaomei Yue

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References

1. Ogurtsova K, Guariguata L, Barengo NC, et al. IDF diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021. Diabetes Res Clin Pract. 2022;183:109118. doi:10.1016/j.diabres.2021.109118. [doi]
2. He D, Hao Z, Zhao M, et al. Structural and functional brain abnormal alteration in patients with type 2 diabetes mellitus: A coordinate-based meta-analysis. Transl Psychiatry. 2025 Aug 6;15(1):269. doi: 10.1038/s41398-025-03488-z. [doi]
3. Vergoossen LW, Schram MT, de Jong JJ, et al. White Matter Connectivity Abnormalities in Prediabetes and Type 2 Diabetes: The Maastricht Study. Diabetes Care. 2020;43(1):201-208. doi:10.2337/dc19-0762. [doi]
4. Sun Y, Ma C, Sun H, et al. Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease. Journal of Diabetes Research. 2020;2020:1-12. doi:10.1155/2020/4981814. [doi]
5. Seidlitz J, Váša F, Shinn M, et al. Morphometric Similarity Networks Detect Microscale Cortical Organization and Predict Inter-Individual Cognitive Variation. Neuron. 2018;97(1):231-247.e7. doi:10.1016/j.neuron.2017.11.039. [doi]
6. Liu Q, Du X, Zhang Y, et al.  Associations between morphometric similarity network and brain gene expression in type 2 diabetes mellitus. Neuroscience. 2025 Apr 19;572:84-92. doi: 10.1016/j.neuroscience.2025.01.053. [doi]
7. Sadler JR, Shearrer GE, Burger KS. Alterations in ventral attention network connectivity in individuals with prediabetes. Nutr Neurosci. 2021 Feb;24(2):140-147. doi: 10.1080/1028415X.2019.1609646. [doi]
8. Geijselaers SLC, Sep SJS, Stehouwer CDA, et al. Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review. Lancet Diabetes Endocrinol. 2015 Jan;3(1):75-89. doi: 10.1016/S2213-8587(14)70148-2. [doi]
9. Liu YH, Chen MT, He YY, et al. Cognitive impairment and depression precede increased HDL-C levels in middle-aged and older Chinese adults: cross-lagged panel analyses. Lipids Health Dis. 2024 Sep 9;23(1):288. doi: 10.1186/s12944-024-02285-9. [doi]

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http://echo.ismrm.org/p/ISMRM2026/468-02-008