Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
563-05-014 ISMRM Abstract

Functional connectome gradient dysfunction in Insomnia Disorder Patients with and without Depression

Primary: Brain Function and fMRI - fMRI Analysis
Secondary: Neuro - Psychiatric Disorders
563-05-014 · fMRI: Task-Based and Stimulation · Wednesday, 13 May, 4:00 PM–4:55 PM · Digital Posters Row D
Keywords: Functional connectivity gradient Insomnia disorder
Accepted
Hui Wang 1,2, Yuanyuan Liu3, Haoyu Chen3, Wei Sheng4, Kai AI5, Yi Zhu6, Wei Chen7, Chiyin Li1, Ming Zhang1,2
1School of Future Technology, Xi'an Jiaotong University, Xi'an, China
2Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
3Xi'an Jiaotong University, Xi'an, China
4MR Research Collaboration Team, Siemens Healthineers Ltd., Chengdu, China
5Department of Clinical and Technical Support, Philips Healthcare (Xi'an), Xi'an, China
6Philips Healthcare (Beijing), Beijing, China
7Department of Medical Imaging Center, Ankang Hospital of Traditional Chinese Medicine, China
Presenting Author: Hui Wang

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References

1. Fang, H., et al., Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment. J Cell Mol Med, 2019. 23(4): p. 2324-2332. doi: 10.1111/jcmm.14170. [doi]
2. Margulies, D.S., et al., Situating the default-mode network along a principal gradient of macroscale cortical organization. Proc Natl Acad Sci U S A, 2016. 113(44): p. 12574-12579. doi: 10.1073/pnas.1608282113. [doi]
3. Chen, M., et al., Aberrant individual large-scale functional network connectivity and topology in chronic insomnia disorder with and without depression. Prog Neuropsychopharmacol Biol Psychiatry, 2025. 136: p. 111158. doi: 10.1016/j.pnpbp.2024.111158. [doi]
4. Schaefer, A., et al., Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI. Cereb Cortex, 2018. 28(9): p. 3095-3114. doi: 10.1093/cercor/bhx179. [doi]
5. Yeo, B.T.T., et al., The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol, 2011. 106(3): p. 1125-65. doi: 10.1152/jn.00338.2011. [doi]
6. Yu, S., et al., The imbalanced anterior and posterior default mode network in the primary insomnia. J Psychiatr Res, 2018. 103: p. 97-103. doi: 10.1016/j.jpsychires.2018.05.013. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/563-05-014