Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
462-04-010 ISMRM Abstract

In Vivo MRI Visualization of the Interstitial Fluid Flow outside of brain in the Vascular Adventitia

Primary: Preclinical Animal & in vitro MR - Small Animals
Secondary: Contrast Mechanisms - Novel Contrast Mechanisms
462-04-010 · Body, Cardiovascular, and Musculoskeletal Systems in Small Animals · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row C
Keywords: Perivascular spaces 9.4T Dynamic Contrast-Enhanced MRI Gadolinium Based Contrast Agents Interstitial fluid flow in adventitia
Accepted
Dong Wei1, Juncen Wu1, Wenchao Yang2, Zijian Zhou 1, Hongyi Li3,4, Peng Hu1,5,6
1School of Biomedical Engineering, ShanghaiTech University, Shanghai, China
2Central Research Institute, United Imaging Healthcare, Shanghai, China
3Research Center for Interstitial Fluid Circulation, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China, Beijing, China
4Department of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China, Beijing, China
5Shanghai Clinical Research and Trial Center, ShanghaiTech University, Shanghai, China
6State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China
Presenting Author: Zijian Zhou

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. J. J. Iliff et al., “A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β,” Sci Transl Med, vol. 4, no. 147, p. 147ra111, Aug. 2012, doi: 10.1126/scitranslmed.3003748. [doi]
2. J. J. Iliff et al., “Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain,” J Neurosci, vol. 33, no. 46, pp. 18190–18199, Nov. 2013, doi: 10.1523/JNEUROSCI.1592-13.2013. [doi]
3. A. Louveau et al., “Structural and functional features of central nervous system lymphatics,” Nature, vol. 523, no. 7560, pp. 337–341, July 2015, doi: 10.1038/nature14432. [doi]
4. H. Mestre et al., “Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension,” Nat Commun, vol. 9, no. 1, p. 4878, Nov. 2018, doi: 10.1038/s41467-018-07318-3. [doi]
5. L. Xie et al., “Sleep Drives Metabolite Clearance from the Adult Brain,” Science, vol. 342, no. 6156, pp. 373–377, Oct. 2013, doi: 10.1126/science.1241224. [doi]
6. Z. H. Gursky et al., “Age-dependent brain responses to mechanical stress determine resilience in a chronic lymphatic drainage impairment model,” Journal of Clinical Investigation, July 2025, doi: 10.1172/jci182555. [doi]
7. H.-Y. Li et al., “Visualized Regional Hypodermic Migration Channels of Interstitial Fluid in Human Beings: Are These Ancient Meridians?,” The Journal of Alternative and Complementary Medicine, vol. 14, no. 6, pp. 621–628, Jul. 2008, doi: 10.1089/acm.2007.0606. [doi]
8. H. Li et al., “Layers of interstitial fluid flow along a ‘slit-shaped’ vascular adventitia,” J. Zhejiang Univ. Sci. B, vol. 22, no. 8, pp. 647–663, Jul. 2021, doi: 10.1631/jzus.B2000590. [doi]
9. H. Li et al., “Longitudinal non-vascular transport pathways originating from acupuncture points in extremities visualised in human body,” Chin. Sci. Bull., vol. 59, no. 35, pp. 5090–5095, Dec. 2014, doi: 10.1007/s11434-014-0633-7. [doi]
10. H. Li et al., “Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration,” iScience, vol. 27, no. 4, p. 109407, Apr. 2024, doi: 10.1016/j.isci.2024.109407. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/462-04-010