Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
531-02-005 / 531-02-005 ISMRM Abstract

Associations of Choroid Plexus Perfusion Measured by pCASL MRI with Amyloid Burden and Cognition in elderly adults

Primary: Neuro - Alzheimer's Disease
Secondary: Contrast Mechanisms - Perfusion
531-02-005 · Imaging Neurodegeneration in Motion: Multimodal Biomarkers for Alzheimer’s Disease and Parkinson’s Disease · Wednesday, 13 May, 1:40 PM–3:16 PM · Roof Terrace
531-02-005 · Imaging Neurodegeneration in Motion: Multimodal Biomarkers for Alzheimer’s Disease and Parkinson’s Disease · Wednesday, 13 May, 1:40 PM–3:16 PM · Roof Terrace
Keywords: Alzheimer's Disease Perfusion Cognition Choroid plexus Arterial Spin Labelling (ASL)
Accepted
Zicheng Wang1,2, Tianrui Zhao1,2, Yining He1,2, Sang Hun Chung 2, Elizabeth Joe3, Helena Chui3, Lirong Yan1,2
1Biomedical Engineering, Northwestern University, Chicago, United States of America
2Radiology, Northwestern University, Chicago, United States of America
3Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, United States of America
Presenting Author: Sang Hun Chung

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References

1. Tarasoff-Conway, J., Carare, R., Osorio, R. et al. Clearance systems in the brain—implications for Alzheimer disease. Nat Rev Neurol 11, 457–470 (2015). https://doi.org/10.1038/nrneurol.2015.119 [doi]
2. Municio C, Carrero L, Antequera D, Carro E. Choroid Plexus Aquaporins in CSF Homeostasis and the Glymphatic System: Their Relevance for Alzheimer’s Disease. International Journal of Molecular Sciences. 2023; 24(1):878. https://doi.org/10.3390/ijms24010878 [doi]
3. Sun, Z., Li, C., Zhang, J. et al. Choroid plexus aging: structural and vascular insights from the HCP-aging dataset. Fluids Barriers CNS 21, 98 (2024). https://doi.org/10.1186/s12987-024-00603-y [doi]
4. Zixuan Liu, Qinyang Shou, Kay Jann, Chenyang Zhao, Danny JJ Wang, Xingfeng Shao, A Test-Retest Study of Single- and Multi-Delay pCASL for Choroid Plexus Perfusion Imaging in Healthy Subjects Aged 19 to 87 Years, NeuroImage, Volume 308, 2025, 121048, ISSN 1053-8119, https://doi.org/10.1016/j.neuroimage.2025.121048. [doi]
5. Buxton, R.B., Frank, L.R., Wong, E.C., Siewert, B., Warach, S. and Edelman, R.R. (1998), A general kinetic model for quantitative perfusion imaging with arterial spin labeling. Magn. Reson. Med., 40: 383-396. https://doi.org/10.1002/mrm.1910400308 [doi]
6. Jiaxin Li, Yuxuan Gao, Yunzhi Xu, Weiying Dai, Yueqin Hu, Xue Feng, Dan Wu, Li Zhao, Morphological changes of the choroid plexus in the lateral ventricle across the lifespan: 5551 subjects from fetus to elderly, NeuroImage, Volume 318,2025, 121392, ISSN 1053-8119, https://doi.org/10.1016/j.neuroimage.2025.121392. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/531-02-005