Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
461-05-011 ISMRM Abstract

Accelerated MCDW-pCASL Using Subspace Low-Rank Reconstruction for Quantification of BBB Water Exchange and Permeability

Primary: Neuro - Aging
Secondary: Acquisition & Reconstruction - Subsampling: Parallel imaging, compressed sensing and low-rank modeling
461-05-011 · Advances in Neuroimaging and Biomarkers for Brain Health and Disease · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row B
Keywords: Permeability Water exchange 3D pCASL Perfusion MRI Low-rank reconstruction
Accepted
Zixuan Liu1,2, Xingfeng Shao3,4, Chenyang Zhao1,5, Ziyang Huang1,5, Fanhua Guo 1, Danny J Wang1,5,6
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States of America
2Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, United States of America
3Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
4Faculty of Medical Imaging Technology, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
5University of Southern California, Los Angeles, United States of America
6USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, United States of America
Presenting Author: Fanhua Guo

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References

1. Knox EG, Aburto MR, Clarke G, Cryan JF, O'Driscoll CM. The blood-brain barrier in aging and neurodegeneration. Mol Psychiatry. 2022;27(6):2659-2673. doi:10.1038/s41380-022-01511-z [doi]
2. Shao X, Ma SJ, Casey M, D'Orazio L, Ringman JM, Wang DJJ. Mapping water exchange across the blood-brain barrier using 3D diffusion-prepared arterial spin labeled perfusion MRI. Magn Reson Med. 2019;81(5):3065-3079. doi:10.1002/mrm.27632 [doi]
3. Shao X, Zhao C, Shou Q, St Lawrence KS, Wang DJJ. Quantification of blood-brain barrier water exchange and permeability with multidelay diffusion-weighted pseudo-continuous arterial spin labeling. Magn Reson Med. 2023;89(5):1990-2004. doi:10.1002/mrm.29581 [doi]
4. Shao X, Zhao C, Guo R, Shou Q, Liang ZP, St Lawrence KS, Wang DJJ. Sub-space low-rank imaging for mapping of blood-brain barrier water exchange rate (SLIWER) using multi-PLD diffusion-weighted pCASL. Proceedings of the International Society for Magnetic Resonance in Medicine (ISMRM); 2025; Toronto, Canada.
5. Shao Xingfeng, Shou Qinyang, Felix Kimberly, Ojogho Brandon, Jiang Xuejuan, Gold Brian T, Herting Megan M, Goldwaser Eric L, Kochunov Peter, Hong L Elliot, Pappas Ioannis, Braskie Meredith, Kim Hosung, Cen Steven, Jann Kay, Wang Danny JJ (2024) Age-Related Decline in Blood-Brain Barrier Function is More Pronounced in Males than Females in Parietal and Temporal Regions eLife 13:RP96155 https://doi.org/10.7554/eLife.96155.2 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/461-05-011