Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
361-04-012 ISMRM Abstract

Towards Robust In Vivo CEST Quantification: Cluster-derived Adaptive Bounds for Z-spectrum Fitting

Primary: Analysis Methods - Data Processing
Secondary: Contrast Mechanisms - CEST / APT / NOE
361-04-012 · Advanced Neuroimaging with MRI: CEST and APT Techniques · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row B
Keywords: Brain Z-spectrum fitting CEST MRI Adaptive Fitting Method Cluster-derived Fitting Bounds
Accepted
Shan Huang1,2, Shihao Zeng1, Huabin Zhang1,3, Gary Kui Kai Lau4,5, Kannie W. Y. Chan6,7,8,9,10,11, Jianpan Huang1,5
1Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
2Department of Engineering, University of Cambridge, Cambridge, United Kingdom
3Medical Imaging Centre, Department of Electronic Engineering and Information Science, University of Science and Technology of China, He Fei, China
4Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
5Tam Wing Fan Neuroimaging Research Laboratory, The University of Hong Kong, Hong Kong, China
6Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America
7Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China
8State Key Laboratory of Terahertz and Millimeter Waves, City University of Hong Kong, Hong Kong, China
9Tung Biomedical Sciences Centre (TBSC), City University of Hong Kong, Hong Kong, China
10Institute of Digital Medicine, City University of Hong Kong, Hong Kong, China
11Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China
Presenting Author: Jiawen Wang

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References

1. Van Zijl PC, Yadav NN. Chemical exchange saturation transfer (CEST): what is in a name and what isn't?. Magnetic resonance in medicine. 2011 Apr;65(4):927-48. https://doi.org/10.1002/mrm.22761 [doi]
2. Zhou IY, Wang E, Cheung JS, Zhang X, Fulci G, Sun PZ. Quantitative chemical exchange saturation transfer (CEST) MRI of glioma using Image Downsampling Expedited Adaptive Least-squares (IDEAL) fitting. Scientific reports. 2017 Mar 7;7(1):84. https://doi.org/10.1038/s41598-017-00167-y [doi]
3. Zaiß M, Schmitt B, Bachert P. Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra. Journal of magnetic resonance. 2011 Aug 1;211(2):149-55. https://doi.org/10.1016/j.jmr.2011.05.001 [doi]
4. Singh A, Debnath A, Cai K, Bagga P, Haris M, Hariharan H, Reddy R. Evaluating the feasibility of creatine‐weighted CEST MRI in human brain at 7 T using a Z‐spectral fitting approach. NMR in Biomedicine. 2019 Dec;32(12):e4176. https://doi.org/10.1002/nbm.4176 [doi]
5. Cai K, Singh A, Poptani H, Li W, Yang S, Lu Y, Hariharan H, Zhou XJ, Reddy R. CEST signal at 2 ppm (CEST@ 2ppm) from Z‐spectral fitting correlates with creatine distribution in brain tumor. NMR in biomedicine. 2015 Jan;28(1):1-8. https://doi.org/10.1002/nbm.3216 [doi]
6. Wang J, Cai P, Wang Z, Zhang H, Huang J. CEST MRI data analysis using Kolmogorov‐Arnold network (KAN) and Lorentzian‐KAN (LKAN) models. Magnetic Resonance in Medicine. 2025 Jun 4. https://doi.org/10.1002/mrm.30548 [doi]
7. Huang J, Lai JH, Tse KH, Cheng GW, Liu Y, Chen Z, Han X, Chen L, Xu J, Chan KW. Deep neural network based CEST and AREX processing: application in imaging a model of Alzheimer’s disease at 3 T. Magnetic resonance in medicine. 2022 Mar;87(3):1529-45. https://doi.org/10.1002/mrm.29044 [doi]
8. Deshmane A, Zaiss M, Lindig T, Herz K, Schuppert M, Gandhi C, Bender B, Ernemann U, Scheffler K. 3D gradient echo snapshot CEST MRI with low power saturation for human studies at 3T. Magnetic resonance in medicine. 2019 Apr;81(4):2412-23. https://doi.org/10.1002/mrm.27569 [doi]
9. Jannah W, Saputro DR. Parameter estimation of Gaussian mixture models (GMM) with expectation maximization (EM) algorithm. InAIP Conference Proceedings 2022 Nov 28 (Vol. 2566, No. 1, p. 040002). AIP Publishing LLC. https://doi.org/10.1063/5.0117119 [doi]

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http://echo.ismrm.org/p/ISMRM2026/361-04-012