Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-04-002 ISMRM Abstract

Deregulation of lipid composition in the breast of BRCA1/2 genetic mutation carriers using chemical shift-encoded imaging

Primary: Body - Breast
Secondary: Acquisition & Reconstruction - Quantitative Imaging: chest, abdomen, and pelvis
460-04-002 · Breast MRI Sequences and Clinical Developments · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row A
Keywords: Breast cancer Early detection Chemical Shift-Encoded MRI Lipid composition BRCA1-2
Accepted
Sai Man Cheung 1, Kwok-Shing Chan2,3, Senthil Kumar Arcot Ragupathy4, Zosia Miedzybrodzka5, Jiabao He1
1Newcastle Magnetic Resonance Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
3Harvard Medical School, Boston, United States of America
4Department of Radiology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom
5Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom
Presenting Author: Sai Man Cheung

Synopsis

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References

1. Pan H, Gray R, Braybrooke J, et al. 20-year risks of breast-cancer recurrence after stopping endocrine therapy at 5 years. N Engl J Med. 2017;377(19):1836-1846. doi: 10.1056/NEJMoa1701830. [doi]
2. Malone KE, Begg CB, Haile RW, et al. Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2. J Clin Oncol. 2010;28(14):2404-2410. doi: 10.1200/JCO.2009.24.2495. [doi]
3. Ramadan S, Arm J, Silcock J, et al. Lipid and metabolite deregulation in the breast tissue of women carrying BRCA1 and BRCA2 genetic mutations. Radiology. 2015;275(3):675-682. doi: 10.1148/radiol.15140967. [doi]
4. Chan KS, Cheung SM, Senn N, et al. Peri-tumoural spatial distribution of lipid composition and tubule formation in breast cancer. BMC Cancer. 2022;22(1):285. doi: 10.1186/s12885-022-09362-1. [doi]
5. Bydder M, Girard O, Hamilton G. Mapping the double bonds in triglycerides. Magn Reson Imaging. 2011;29(8):1041-1046. doi: 10.1016/j.mri.2011.07.004. [doi]
6. Peterson P, Månsson S. Simultaneous quantification of fat content and fatty acid composition using MR imaging. Magn Reson Med. 2013;69(3):688-697. doi: 10.1002/mrm.24297. [doi]
7. Broadfield LA, Pane AA, Talebi A, Swinnen JV, Fendt S. Lipid metabolism in cancer: New perspectives and emerging mechanisms. Dev Cell. 2021;56(10):1363-1393. doi: 10.1016/j.devcel.2021.04.013. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/460-04-002