404-02-008 ISMRM Abstract

Glycine as an Imaging Biomarker of Rapid Glioma Proliferation and Predictor of Recurrence: A Study With Glycine-Targeted MRS

Primary: Neuro - Tumors

Secondary: Physics & Engineering - RF Pulse Design & Fields

404-02-008 · Altered Metabolism Across Healthy Aging and Neurological Disorders · Tuesday, 12 May, 8:20 AM–10:10 AM · Ballroom East

Keywords: Glioma Recurrence prediction Glycine Proliferation Glycine-Targeted MRS

Accepted

Xiaozhu Hao ¹, Kai Huang², Yefeng Yao², Zhenwei Yao¹

¹Huashan Hospital, Fudan University, China

²Shanghai Key Laboratory of Magnetic Resonance, Shanghai, China

Presenting Author: Xiaozhu Hao

Synopsis

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References

1. JAIN M, NILSSON R, SHARMA S, et al. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation [J]. Science, 2012, 336(6084): 1040-4. PMID: 22628656. [pmid]

2. LOCASALE J W, et al. Serine, glycine and one-carbon units: cancer metabolism in full circle [J]. Nat Rev Cancer, 2013, 13(8): 572-83. PMID: 23822983. [pmid]

3. TIWARI V, DAOUD E V, HATANPAA K J, et al. Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness [J]. Neuro Oncol, 2020, 22(7): 1018-29. PMID: 32055850. [pmid]

4. GANJI S K, MAHER E A, CHOI C, et al. In vivo (1)H MRSI of glycine in brain tumors at 3T [J]. Magn Reson Med, 2016, 75(1): 52-62. PMID: 25651788. [pmid]

5. MAUDSLEY A A, GUPTA R K, STOYANOVA R, et al. Mapping of glycine distributions in gliomas [J]. AJNR Am J Neuroradiol, 2014, 35(6 Suppl): S31-6. PMID: 24481330. [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/404-02-008