Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-03-012 ISMRM Abstract

DTI-ALPS Quantification of Glymphatic Impairment Across Sleep Disorder phenotypes and Its Correlation with Symptom Severity

Primary: Neuro - Neurofluids
Secondary: Diffusion - DWI/DTI/DKI
663-03-012 · Glymphatic System Imaging: From Neurofluid Transport to Neurodegeneration · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row D
Keywords: Neurofluids Glymphatic system DTI-ALPS Sleep disorders Perivascular diffusion
Accepted
Yasmine Saad 1, Nader Gharbia2, Aymen Kammoun3, Rihab Ben Dhia1, Najes Gouta1, Meriem Mhiri1, Mahbouba Frih Ayed1
1Faculty of Medicine of Monastir, Tunisia
2Faculty of medicine of Sfax, Tunisia
3Faculty of Sciences of Monastir, Tunisia
Presenting Author: Yasmine Saad

Synopsis

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References

1. Benveniste H, Liu X, Koundal S, Sanggaard S, Lee H, Wardlaw J. The Glymphatic System and Waste Clearance with Brain Aging: A Review. Gerontology. 2019;65(2):106-119. doi: 10.1159/000490349. [doi]
2. Jin Y, Zhang W, Yu M, Li J, Du Y, Wang W, Chen G, Ding X, Ding J. Glymphatic system dysfunction in middle-aged and elderly chronic insomnia patients with cognitive impairment evidenced by diffusion tensor imaging along the perivascular space (DTI-ALPS). Sleep Med. 2024 Mar;115:145-151. doi: 10.1016/j.sleep.2024.01.028. [doi]
3. Liu H, Yang S, He W, Liu X, Sun S, Wang S, Wang Y, Zhou X, Tang T, Xia J, Liu Y, Huang Q. Associations Among Diffusion Tensor Image Along the Perivascular Space (DTI-ALPS), Enlarged Perivascular Space (ePVS), and Cognitive Functions in Asymptomatic Patients With Carotid Plaque. Front Neurol. 2022 Jan 4;12:789918. doi: 10.3389/fneur.2021.789918. [doi]
4. Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M. Sleep drives metabolite clearance from the adult brain. Science. 2013 Oct 18;342(6156):373-7. doi: 10.1126/science.1241224. [doi]
5. Taoka T, Ito R, Nakamichi R, Nakane T, Kawai H, Naganawa S. Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method. Magn Reson Med Sci. 2024 Jul 1;23(3):268-290. doi: 10.2463/mrms.rev.2023-0175. [doi]
6. Ringstad, G. Glymphatic imaging: a critical look at the DTI-ALPS index. Neuroradiology 66, 157–160 (2024). https://doi.org/10.1007/s00234-023-03270-2. [doi]
7. Haller S, Moy L, Anzai Y. Evaluation of Diffusion Tensor Imaging Analysis Along the Perivascular Space as a Marker of the Glymphatic System. Radiology. 2024 Jan;310(1):e232899. doi: 10.1148/radiol.232899. [doi]
8. Trotti LM, Bliwise DL. Brain MRI findings in patients with idiopathic hypersomnia. Clin Neurol Neurosurg. 2017 Jun;157:19-21. doi: 10.1016/j.clineuro.2017.03.010. [doi]

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http://echo.ismrm.org/p/ISMRM2026/663-03-012