Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
367-05-015 ISMRM Abstract

MRI-Based Brain Aging Models Reveal Specific Atrophy Patterns in Multiple Sclerosis according to Age, Sex, and Age at Onset

Primary: Neuro - Multiple Sclerosis
Secondary: Neuro - Aging
367-05-015 · Neuroinflammation: Myelin and Iron · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row H
Keywords: Neurodegeneration
Accepted
Loredana Storelli1, Paolo Preziosa1,2,3, Alessandro Meani1, Antonio Gallo4,5, Alessandro d'Ambrosio4,5, Patrizia Pantano6,7,8, Claudia Piervincenzi7, Nicola De Stefano9, Rosa Cortese9, Paola Valsasina 1, Elisabetta Pagani1, Massimo Filippi1,2,3,10,11, Maria A. Rocca1,2,3
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy
2Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
3Vita-Salute San Raffaele University, Milan, Italy
4Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy
5First Division of Neurology and Neurophysiopathology, AOU Luigi Vanvitelli, Naples, Italy
6Sapienza University of Rome, Rome, Italy
7Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy
8IRCCS Neuromed, Pozzilli (IS), Italy
9Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy
10Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
11Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy
Presenting Author: Paola Valsasina

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References

1. Blinkouskaya Y, Cacoilo A, Gollamudi T, Jalalian S, Weickenmeier J. Brain aging mechanisms with mechanical manifestations. Mech Ageing Dev 2021;200:111575. doi: 10.1016/j.mad.2021.111575 [doi]
2. Filippi M, Preziosa P, Barkhof F, et al. The ageing central nervous system in multiple sclerosis: the imaging perspective. Brain 2024;147:3665-3680. doi: 10.1093/brain/awae251 [doi]
3. Rocca MA, Preziosa P, Filippi M. Age Matters in Multiple Sclerosis: Novel Insights Into Disease Progression From Clinical Onset. Neurology 2025;104:e213396. doi: 10.1212/WNL.0000000000213396 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/367-05-015