666-03-011 ISMRM Abstract

Multimodal non-invasive interrogation of chemo-brain using hyperpolarized magnetic resonance and optical imaging

Primary: Neuro - Other Neurodegeneration

Secondary: Preclinical Animal & in vitro MR - Biomarkers

666-03-011 · Neuro-Biomarkers · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row G

Keywords: Hyperpolarized MR (Non-Gas) Cognitive impairment Chemotherapy Optical imaging Chemo-brain

Accepted

Muxin Wang^1,2, Xudong Qiu¹, Bill T Sun¹, José S Enriquez^1,2, Julia R Zickus ^1,2, Jorge DeLaCerda¹, Aldo Morales¹, Khloe L Kelley¹, Seth T Gammon¹, David Piwnica-Worms^1,2, Chengyue Wu^2,3,4,5,6,7, Peter Grace^2,8, Komal Shah⁹, Pratip K Bhattacharya^1,2

¹Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, United States of America

²The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, United States of America

³Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, United States of America

⁴Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, United States of America

⁵Department of Breast Imaging, The University of Texas MD Anderson Cancer Center, Houston, United States of America

⁶Institute for Data Science in Onocology, The University of Texas MD Anderson Cancer Center, Houston, United States of America

⁷Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, United States of America

⁸Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, United States of America

⁹Department of Neuroradiology, The University of Texas MD Anderson Cancer Center, Houston, United States of America

Presenting Author: Julia R Zickus

Synopsis

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References

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2. Sioka C, Kyritsis AP. Central and peripheral nervous system toxicity of common chemotherapeutic agents. Cancer Chemother Pharmacol. 2009 Apr;63(5):761-7.

3. Miyashita M. Chemotherapy-related cognitive impairment: What we need to know and what we can do. Asia Pac J Oncol Nurs. 2023 Nov 7;11(1):100334.

4. Chiang ACA, Huo X, Kavelaars A, Heijnen CJ. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain Behav Immun. 2019 Jul;79:319-325.

5. Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB. Hyperpolarized 13C MRI: State of the Art and Future Directions. Radiology. 2019 May;291(2):273-284. doi: 10.1148/radiol.2019182391. Epub 2019 Mar 5. PMID: 30835184; PMCID: PMC6490043. [doi] [pmid]

6. Le Roux LG, Qiu X, Jacobsen MC, Pagel MD, Gammon ST, Piwnica-Worms DR, Schellingerhout D. Axonal Transport as an In Vivo Biomarker for Retinal Neuropathy. Cells. 2020 May 22;9(5):1298. doi: 10.3390/cells9051298. PMID: 32456061; PMCID: PMC7291064. [doi] [pmid]

7. Ma J, Huo X, Jarpe MB, Kavelaars A, Heijnen CJ. Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment. Acta Neuropathol Commun. 2018 Oct 1;6(1):103.

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http://echo.ismrm.org/p/ISMRM2026/666-03-011