Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
662-02-009 ISMRM Abstract

In Vitro Characterization of a R3-Noria-methanesulfonate Cage Variant Featuring Promising Biocompatibility for HyperCEST MRI

Primary: Contrast Mechanisms - Hyperpolarized MR (Gas)
Secondary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
662-02-009 · Advances in Chemical Exchange MRI: CEST, APT, and NOE II · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row C
Keywords: Molecular Imaging HyperCEST Hyperpolarized Xenon-129 MRI Biocompatibility assessment Supramolecular cage
Accepted
Viktoriia Batarchuk1,2, Yurii Shepelytskyi1,2, Janika Martikainen Ramirez3, Bianca C Zussino2,3, Yieun Kim3, Mackenzie D Dillon1, Guillem Dayer2,3, Carson L Hasselbrink4, Mitchell Albert 2,5
1Chemistry, Lakehead University, Thunder Bay, Canada
2Thunder Bay Regional Health Research Institute, Thunder Bay, Canada
3Biology, Lakehead University, Thunder Bay, Canada
4Chemistry & Biochemistry, California Polytechnic State University, San Luis Obispo, United States of America
5Lakehead University, Thunder Bay, Canada
Presenting Author: Mitchell Albert

Synopsis

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References

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3. Shuvaev S, Akam E, Caravan P. Molecular MR Contrast Agents. Invest Radiol. 2021 Jan;56(1):20-34, https://doi.org/10.1097/RLI.0000000000000731 [doi]
4. Albert, M. S., et al. "Biological magnetic resonance imaging using laser-polarized 129Xe." Nature 370.6486 (1994): 199-201, https://doi.org/10.1038/370199a0 [doi]
5. Schröder, L. "Xenon Biosensor HyperCEST MRI." Hyperpolarized and Inert Gas MRI. Academic Press, 2017. 263-277. Academic Press, 2017. 263-277, https://doi.org/10.1016/B978-0-12-803675-4.00017-8 [doi]
6. Batarchuk, Viktoriia, et al. "Hyperpolarized Xenon-129 chemical exchange saturation transfer (HyperCEST) molecular imaging: achievements and future challenges." International Journal of Molecular Sciences 25.3 (2024): 1939, https://doi.org/10.3390/ijms25031939 [doi]
7. Shepelytskyi, Yurii, et al. "R3-Noria-methanesulfonate: a molecular cage with superior hyperpolarized Xenon-129 MRI contrast." ACS sensors 8.12 (2023): 4707-4715, https://doi.org/10.1021/acssensors.3c01791 [doi]
8. Du, Kang, et al. "Paramagnetic organocobalt capsule revealing xenon host–guest chemistry." Inorganic chemistry 59.19 (2020): 13831-13844, https://dx.doi.org/10.1021/acs.inorgchem.9b03634?ref=pdf [doi]
9. Hane, Francis T., et al. "In vivo detection of cucurbit [6] uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor." Scientific Reports 7.1 (2017): 41027, https://doi.org/10.1038/srep41027 [doi]
10. McHugh, Christian T., et al. "In vivo hyperCEST imaging: Experimental considerations for a reliable contrast." Magnetic resonance in medicine 87.3 (2022): 1480-1489, https://doi.org/10.1002/mrm.29032 [doi]
11. Kern, Agilo Luitger, et al. "Compartment-specific 129Xe HyperCEST z spectroscopy and chemical shift imaging of cucurbit [6] uril in spontaneously breathing rats." Zeitschrift für Medizinische Physik (2023), https://doi.org/10.1016/j.zemedi.2023.08.005 [doi]
12. Assay, Cell Proliferation, and Cytotoxicity Assay. "Cell Counting Kit-8 Technical Manual." Kumamoto: Dojindo Laboratories (2013).

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http://echo.ismrm.org/p/ISMRM2026/662-02-009