Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
361-04-005 ISMRM Abstract

Double-Step R1rho-Based Lorentzian Fitting with A Full Steady-State Model Enables Fast CEST Imaging of Acute Ischemic Stroke

Primary: Contrast Mechanisms - CEST / APT / NOE
Secondary: Acquisition & Reconstruction - Signal Modeling
361-04-005 · Advanced Neuroimaging with MRI: CEST and APT Techniques · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row B
Keywords: Stroke CEST MRI Postprocessing
Accepted
Shihao Zeng1, Huabin Zhang1,2, Shan Huang1,3, Gary Kui Kai Lau4,5, Kannie W. Y. Chan6,7,8,9,10,11, Jianpan Huang 1,5
1Department of Diagnostic Radiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
2Medical Imaging Center, Department of Electronic Engineering and Information Science, University of Science and Technology of China, He Fei, China
3Department of Engineering, University of Cambridge, Cambridge, United Kingdom
4Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
5Tam Wing Fan Neuroimaging Research Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
6Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China
7Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, China
8Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America
9State Key Laboratory of Terehertz and Millimeter Waves, City University of Hong Kong, Hong Kong, China
10Tung Biomedical Sciences Centre (TBSC), City University of Hong Kong, Hong Kong, China
11Institute of Digital Medicine, City University of Hong Kong, Hong Kong, China
Presenting Author: Jianpan Huang

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References

1. Huang J, Chan MYM, Zhang Y, Lau GKK, Chan KWY. Assessment of molecular and pH weighted signal changes in chronic ischemic stroke using CEST MRI at 3T. 2025 10/05–15/05; Honolulu, Hawaiʻi, USA.
2. Zhou J, Heo HY, Knutsson L, van Zijl PCM, Jiang S. APT-weighted MRI: Techniques, current neuro applications, and challenging issues. J Magn Reson Imaging 2019;50(2):347–364. https://doi.org/10.1002/jmri.26645 [doi]
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5. Sun PZ. Quasi-steady state chemical exchange saturation transfer (QUASS CEST) analysis-correction of the finite relaxation delay and saturation time for robust CEST measurement. Magn Reson Med 2021;85(6):3281–3289. https://doi.org/10.1002/mrm.28653 [doi]
6. Zhang XY, Zhai Y, Jin Z, Li C, Sun PZ, Wu Y. Preliminary demonstration of in vivo quasi‐steady‐state CEST postprocessing—Correction of saturation time and relaxation delay for robust quantification of tumor MT and APT effects. Magnetic Resonance in Medicine 2021;86(2):943–953. https://doi.org/10.1002/mrm.28764 [doi]
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11. Zhang H, Zeng S, Wang J, Cai P, Wang Z, Chen L, Qiu B, Huang J. Double‐Step R1rho‐Based Lorentzian Fitting (DROF): A New CEST Analysis Approach and Its Comparison With Existing Methods. NMR in Biomedicine 2025;38(8):e70082. https://doi.org/10.1002/nbm.70082 [doi]
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http://echo.ismrm.org/p/ISMRM2026/361-04-005