Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
668-02-010 ISMRM Abstract

Mapping of GABA and Glutamate in Tuberous Sclerosis Complex Using Edited-MRSI at 3T

Primary: Pediatrics - Neuro
Secondary: Neuro - Epilepsy
668-02-010 · Spectroscopy and Spectroscopic Imaging: Applications · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row I
Keywords: Pediatric Epilepsy Neurometabolites 1H MRS 1H-MRSI
Accepted
Dillip K. Senapati 1, Helge Zoellner1, İpek Özdemir1, Georg Oeltzschner1, Ryan Gill1,2, Jacqueline Harris1,2, Peter B Barker1,2, Doris Lin1,2
1Johns Hopkins University School of Medicine, Baltimore, United States of America
2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States of America
Presenting Author: Dillip K. Senapati

Synopsis

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References

1. Northrup H, Aronow ME, Bebin EM, et al. Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations. Pediatr Neurol. 2021;123:50-66.
2. Mori K, Mori T, Toda Y, et al. Decreased benzodiazepine receptor and increased GABA level in cortical tubers in tuberous sclerosis complex. Brain Dev. 2012;34:478-486.
3. Taki MM, Harada M, Mori K, et al. High gamma-aminobutyric acid level in cortical tubers in epileptic infants with tuberous sclerosis complex measured with the MEGA-editing J-difference method and a three-Tesla clinical MRI Instrument. Neuroimage. 2009;47:1207-1214.
4. Zhu H, Edden RAE, Ouwerkerk R, Barker PB. High resolution spectroscopic imaging of GABA at 3 Tesla. Magn Reson Med. 2011;65(3):603-609.
5. Zhu H, Ouwerkerk R, Barker PB. Dual-Band Water and Lipid Suppression for MR Spectroscopic Imaging at 3 Tesla. Magn. Reson Med. 2010;63:1486–1492.
6. Zöllner HJ, Senapati DK, Özdemir İ, et al. Reproducibility of metabolic mapping using 2D multi-slice short-TE and GABA-edited spin-echo MRSI at 3T in a single protocol. NMR in Biomed 2025 (in press).
7. Oeltzschner G, Zöllner HJ, Hui SCN, et al. Osprey: Open-source processing, reconstruction & estimation of magnetic resonance spectroscopy data. J Neurosci Methods. 2020;343:108827.
8. Chan KL, Barker PB. Retrospective motion compensation for edited MR spectroscopic imaging. NeuroImage. 2019;202:116141.
9. Hui SCN, Saleh MG, Zöllner HJ et al. MRSCloud: A cloud-based MRS tool for basis set simulation. Magn Reson Med. 2022;88:1994–2004.
10. McCarthy P. FSLeyes. Published online October 2021.
11. Aasly J, Silfvenius H, Aas TC, et al. Proton magnetic resonance spectroscopy of brain biopsies from patients with intractable epilepsy. Epilepsy Research. 1999;35:211–217.
12. Sarlo GL, Holton KF. Seizure: European Journal of Epilepsy. 2021;91:213–227.
13. Senapati DK, Zöllner HJ, Özdemir İ, et al. Mapping brain metabolism in Tuberous Sclerosis Complex: a 3T MRSI study. AJNR(in press)
14. White R, BA, Hua Y, et al. Selective Alterations in Glutamate and GABA Receptor Subunit mRNA Expression in Dysplastic Neurons and Giant Cells of Cortical Tubers. Ann Neurol. 2001;49:67–78.
15. Wong M, Ess KC, Uhlmann EJ, et al. Impaired Glial Glutamate Transport in a Mouse Tuberous Sclerosis Epilepsy Model. Ann Neurol. 2003;54:251–256.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/668-02-010