Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
530-03-010 ISMRM Abstract

IVIg Delivery to the Motor Cortex in Amyotrophic Lateral Sclerosis Patients using a Novel MR-Guided Focused Ultrasound System

Primary: Neuro - Neurotherapeutics
Secondary: Neuro - Other Neurodegeneration
530-03-010 · Interventional MRI: Tracking, Temperature Mapping, and Image-Guided Therapy · Wednesday, 13 May, 1:40 PM–3:30 PM · Meeting Room 2.60
Keywords: Focused Ultrasound MR-Guided Interventions Blood brain barrier Amyotrophic lateral sclerosis Transcranial focused ultrasound
Accepted
Ryan M Jones1, Dallan McMahon1, Pedro Saldanha de Castro2,3, Yuexi Huang1, Ying Meng3,4, Benjamin Davidson3,4, Clement Hamani3,4, Isabelle Aubert5,6, Lorne Zinman2,7, Agessandro Abrahao2,3,7, Nir Lipsman1,3,4, Kullervo Hynynen 1,8
1Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
2Institute of Medical Science, University of Toronto, Toronto, Canada
3Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, Canada
4Department of Surgery, University of Toronto, Toronto, Canada
5Biological Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
6Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
7Evaluative Clinical Sciences Platform, Sunnybrook Research Institute, Toronto, Canada
8Department of Medical Biophysics, University of Toronto, Toronto, Canada
Presenting Author: Kullervo Hynynen

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References

1. Mainprize T, Lipsman N, Huang Y, et al. Blood-brain barrier opening in primary brain tumors with non-invasive MR-guided focused ultrasound: a clinical safety and feasibility study. Sci Rep. 2019;9:321. doi: 10.1038/s41598-018-36340-0 [doi]
2. Lipsman N, Meng Y, Bethune AJ, et al. Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound. Nat Commun. 2018;9:2336. doi: 10.1038/s41467-018-04529-6 [doi]
3. Abrahao A, Meng Y, Llinas M, et al. First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound. Nat Commun. 2019;10:4373. doi: 10.1038/s41467-019-12426-9 [doi]
4. Meng Y, Pople CB, Huang Y, et al. Putaminal recombinant glucocerebrosidase delivery with magnetic resonance-guided focused ultrasound in Parkinson's disease: a phase I study. Mov Disord. 2022;37:2134-9. doi: 10.1002/mds.29190 [doi]
5. McMahon D, Jones RM, Ramdoyal R, et al. Investigation of sonication parameters for large-volume focused ultrasound-mediated blood–brain barrier permeability enhancement using a clinical-prototype hemispherical phased array. Pharmaceutics. 2024;16:1289. doi:10.3390/pharmaceutics16101289 [doi]
6. Jones RM, Deng L, Leung K, et al. Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening. Theranostics. 2018;8:2909-26. doi:10.7150/thno.24911 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/530-03-010