Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
331-01-006 / 331-01-006 ISMRM Abstract

Multimodal MRI Characterization of Pregnancy-Related Structural and Functional Brain Reorganization in Mice

Primary: Preclinical Animal & in vitro MR - Small Animals
Secondary: Brain Function and fMRI - Functional Connectivity
331-01-006 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
331-01-006 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
Keywords: Diffusion Tensor Imaging Resting-state fMRI Pregnancy Animal mouse model
Accepted
Kavita Singh 1,2, Alexandru Korotcov1,2, Marena M Kutschman3, Temitope Adebayo1,2, Salsabila Purnomuo1,2, Sarah K Anisowicz4, Maureen Hood1,2, John T Wu5
1Department of Radiology and Bioengineering, Uniformed Services University of the Health Sciences, Bethesda, United States of America
2Biomedical Research Imaging Core at Uniformed Services University, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20814, United States of America
3School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, United States of America
4Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, United States of America
5Department of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, United States of America
Presenting Author: Kavita Singh

Synopsis

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References

1. Hoekzema, E. et al. Pregnancy leads to long-lasting changes in human brain structure. Nat. Neurosci. 20, 287–296 (2017).
2. Pritschet, L. et al. Neuroanatomical changes observed over the course of a human pregnancy. Nat. Neurosci. 27, 2253–2260 (2024).
3. Niu, Y. et al. Longitudinal Investigation of Neurobiological Changes Across Pregnancy. 2024.03.08.584178 Preprint at https://doi.org/10.1101/2024.03.08.584178 (2024). [doi]
4. Hoekzema, E. et al. Mapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture. Nat. Commun. 13, 6931 (2022).
5. (ISMRM 2025) Structural MRI Analysis of Pregnancy-Related Brain Region Volumetric Changes in Mice: A Step Toward a Translational Animal Model. https://archive.ismrm.org/2025/0835.html.
6. Oatridge, A. et al. Change in Brain Size during and after Pregnancy: Study in Healthy Women and Women with Preeclampsia. Am. J. Neuroradiol. 23, 19–26 (2002).
7. Pierpaoli, C. et al. TORTOISE: an integrated software package for processing of diffusion MRI data.
8. Avants, B. B. et al. The optimal template effect in hippocampus studies of diseased populations. NeuroImage 49, 2457–2466 (2010).
9. Ma, Y. et al. In Vivo 3D Digital Atlas Database of the Adult C57BL/6J Mouse Brain by Magnetic Resonance Microscopy. Front. Neuroanat. 2, 1 (2008).
10. Barba-Müller, E., Craddock, S., Carmona, S. & Hoekzema, E. Brain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health. Arch. Womens Ment. Health 22, 289–299 (2019).
11. Spalek, K. et al. Pregnancy renders anatomical changes in hypothalamic substructures of the human brain that relate to aspects of maternal behavior. Psychoneuroendocrinology 164, 107021 (2024).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/331-01-006