Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
367-03-015 ISMRM Abstract

Assessing Muscle Perfusion and Microstructure in Aging with Flow-Compensated IVIM MRI

Primary: Musculoskeletal - Muscle
Secondary: Diffusion - IVIM
367-03-015 · Muscle Microstructure and Deformation · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row H
Keywords: Aging Musculoskeletal MRI Skeletal Muscle Flow compensation Intravoxel incoherent motion (IVIM)
Accepted
Sofia Nikolaidou 1,2,3, Eric Sigmund1,2, Omar Darwish4, Smita Rao5, Valentina Mazzoli1,2
1Center for Advanced Imaging Innovation and Research (CAI²R), New York University Grossman School of Medicine, New York, United States of America
2Department of Radiology, NYU Langone Health, New York, United States of America
3Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, United States of America
4MR Application Predevelopment, Erlangen, Germany
5Department of Physical Therapy, New York University, New York, United States of America
Presenting Author: Sofia Nikolaidou

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References

1. Englund, E. K., Reiter, D. A., Shahidi, B., & Sigmund, E. E. (2022). Intravoxel incoherent motion magnetic resonance imaging in skeletal muscle: Review and future directions. Journal of Magnetic Resonance Imaging, 55(4), 988–1012. https://doi.org/10.1002/jmri.27875 [doi]
2. Adelnia, F., Shardell, M., Bergeron, C. M., et al. (2019). Diffusion-weighted MRI with intravoxel incoherent motion modeling for assessment of muscle perfusion in the thigh during post-exercise hyperemia in younger and older adults. NMR in Biomedicine, 32(5), e4072. https://doi.org/10.1002/nbm.4072 [doi]
3. Landers-Ramos, R. Q., & Prior, S. J. (2018). The microvasculature and skeletal muscle health in aging. Exercise and Sport Sciences Reviews, 46(3), 172–179. https://doi.org/10.1249/JES.0000000000000151 [doi]
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6. Lemberskiy, G., Feiweier, T., Gyftopoulos, S., Axel, L., Novikov, D. S., & Fieremans, E. (2021). Assessment of myofiber microstructure changes due to atrophy and recovery with time-dependent diffusion MRI. NMR in Biomedicine, 34(7), e4534. https://doi.org/10.1002/nbm.4534 [doi]
7. Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., Schneider, S. M., Sieber, C. C., Topinkova, E., Vandewoude, M., Visser, M., & Zamboni, M.; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), & the Extended Group for EWGSOP2. (2019). Sarcopenia: Revised European consensus on definition and diagnosis. Age and Ageing, 48(1), 16–31. https://doi.org/10.1093/ageing/afy169 [doi]
8. Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., & McBurnie, M. A.; Cardiovascular Health Study Collaborative Research Group. (2001). Frailty in older adults: Evidence for a phenotype. The Journals of Gerontology: Series A, Biological Sciences and Medical Sciences, 56(3), M146–M156. https://doi.org/10.1093/gerona/56.3.m146 [doi]

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http://echo.ismrm.org/p/ISMRM2026/367-03-015