Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
402-03-002 ISMRM Abstract

Quantitative High-Resolution Metabolic Imaging of the Human Brain

Primary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
Secondary: Contrast Mechanisms - Spectroscopy
402-03-002 · Metabolic Imaging and MR Spectroscopy: Methods and Application · Tuesday, 12 May, 1:40 PM–3:30 PM · Hall 1B
Keywords: Metabolic imaging Quantitative Imanging Magnetic resonance spectroscopic imaging
Accepted
Yibo Zhao 1, Yudu Li1,2,3, Rong Guo1,4, Wen Jin1,5, Yao Li6, Bradley Sutton1,2,3, Zhi-Pei Liang1,5
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, United States of America
2Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, United States of America
3National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Champaign, United States of America
4Siemens Medical Solutions USA, Inc., Malvern, United States of America
5Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Champaign, United States of America
6School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Presenting Author: Yibo Zhao

Synopsis

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References

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2. Posse S, Otazo R, Dager SR, Alger J. MR spectroscopic imaging: Principles and recent advances. Journal of Magnetic Resonance Imaging. 2013;37(6):1301-1325. doi:10.1002/jmri.23945 [doi]
3. Zhao Y, Li Y, Jin W, et al. Ultrafast J-resolved magnetic resonance spectroscopic imaging for high-resolution metabolic brain imaging. Nat Biomed Eng. Published online June 20, 2025. doi:10.1038/s41551-025-01418-4 [doi]
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11. Maudsley AA, Domenig C, Govind V, et al. Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). Magn Reson Med. 2009;61(3):548-559. doi:10.1002/mrm.21875 [doi]
12. Ke Z, Zhao Y, Guo R, et al. Motion correction in high‐resolution 3D brain MRSI without water and lipid suppression. Magn Reson Med. Published online October 10, 2025. doi:10.1002/mrm.70128 [doi]
13. Guo R, Zhao Y, Li Y, et al. Simultaneous QSM and metabolic imaging of the brain using SPICE: Further improvements in data acquisition and processing. Magn Reson Med. 2021;85(2):970-977. doi:10.1002/mrm.28459 [doi]
14. Liang ZP. Spatiotemporal imaging with partially separable functions. In: Proc. IEEE Int. Symp. Biomed. Imag. 2007:988-991. doi:10.1109/ISBI.2007.357020 [doi]
15. Zhao Y, Li Y, Guo R, et al. Accelerated 3D metabolite T1 mapping of the brain using variable‐flip‐angle SPICE. Magn Reson Med. 2024;92(4):1310-1322. doi:10.1002/mrm.30200 [doi]
16. Zhang T, Zhao Y, Jin W, et al. B1 mapping using pre‐learned subspaces for quantitative brain imaging. Magn Reson Med. 2023;90(5):1-13. doi:10.1002/mrm.29764 [doi]
17. Ma C, Lam F, Johnson CL, Liang ZP. Removal of nuisance signals from limited and sparse 1H MRSI data using a union-of-subspaces model. Magn Reson Med. 2016;75(2):488-497. doi:10.1002/mrm.25635 [doi]
18. Zhao Y, Li Y, Guo R, et al. B1 correction of MRSI data using unsuppressed water signals. In: Annual Meeting of International Society for Magnetic Resonance in Medicine. 2025:1692.
19. Li Y, Guo R, Zhao Y, et al. Rapid high-resolution simultaneous acquisition of metabolites, myelin water fractions, and tissue susceptibility of the whole brain using “SPICY” 1H-MRSI. In: Annual Meeting of International Society for Magnetic Resonance in Medicine. 2019:0946.

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http://echo.ismrm.org/p/ISMRM2026/402-03-002