Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
352-03-004 / 352-03-004 ISMRM Abstract

Resting-State Functional MRI Marker of Glymphatic Dysfunction in Chronic Insomnia Disorder

Primary: Neuro - Neurofluids
Secondary: Brain Function and fMRI - fMRI Analysis
352-03-004 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
352-03-004 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
Keywords: Glymphatics Cerebrospinal fluid Resting-state fMRI Chronic Insomnia Disorder
Accepted
Aaron E Carretero Benites1, Zhuohui Huang2, Shuo Zheng2, Xinlan Zhang3, Cailan Hou2, Chuan Huang1,3
1Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, United States of America
2Guangdong Mental Health Center, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, GuangDong, Guangzhou, China
3Radiology & Imaging Sciences, Emory University, Atlanta, United States of America
Presenting Author: Candace C Fleischer

Synopsis

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References

1. Xie L, Kang H, Xu Q, et al. Sleep Drives Metabolite Clearance from the Adult Brain. Science. 2013;342(6156):373-377. doi:10.1126/science.1241224 [doi]
2. Nedergaard M, Goldman SA. Glymphatic failure as a final common pathway to dementia. Science. 2020;370(6512):50-56. doi:10.1126/science.abb8739 [doi]
3. Zhong S, He Y, Chen K, et al. Altered neurovascular-cerebrospinal fluid synergy in chronic insomnia disorder. Sleep Medicine. September 2025:106815. doi:10.1016/j.sleep.2025.106815 [doi]
4. Fultz NE, Bonmassar G, Setsompop K, et al. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019;366(6465):628-631. doi:10.1126/science.aax5440 [doi]
5. Han F, Chen J, Belkin-Rosen A, et al. Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease–related pathology. PLOS Biology. 2021;19(6):e3001233. doi:10.1371/journal.pbio.3001233 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/352-03-004