Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
470-11-160 ISMRM Abstract

7T MRSI Biomarkers in Gliomas: Quantitative comparison through Multimodal Correlation with Mass Spectrometry

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Neuro - Tumors
470-11-160 · Spectroscopy Traditional Posters · Tuesday, 12 May, 4:55 PM–5:50 PM · Traditional Posters | Exhibition Hall
Keywords: Glioma Neurosurgery MRSI 7 Tesla Mass spectrometry
Accepted
Sagar Acharya 1,2,3, Cornelius Cadrien1,2, Sara Huskic1,2, Philipp Lazen1,2, Ahmet Azgın1, Barbara Kiesel2, Lisa Koerner2, Daniela Lötsch-Gojo4, Vitalij Zeiser4, Julia Furtner1, Juliane Hennenberg4, Matthias Preusser5, Thomas Roetzer-Pejrimovsky6, Gunda Köllensperger7, Christina Brenner7, Patrick Hiepe8, Wolfgang Bogner1, Georg Widhalm2, Karl Rössler2, Gilbert Hangel1,2,3
1Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria
2Department of Neurosurgery, Medical University of Vienna, Vienna, Austria
3Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria
4Medical University of Vienna, Vienna, Austria
5Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria
6Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria
7Institute for Analytical Chemistry, University of Vienna, Vienna, Austria
8Brainlab AG Munich, Munich, Germany
Presenting Author: Sagar Acharya

Synopsis

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References

1. 1) Moser, E. (2012). 7-T MR—from research to clinical applications? PubMed. Retrieved November 5, 2023, from https://pubmed.ncbi.nlm.nih.gov/22102481/ [pmid]
2. 2) Hangel, G.; Cadrien, C.; Lazen, P.; Furtner, J.; Lipka, A.; Hečková, E.; Hingerl, L.; Motyka, S.; Gruber, S.; Strasser, B.; Kiesel, B.; Mischkulnig, M.; Preusser, M.; Roetzer-Pejrimovsky, T.; Wöhrer, A.; Widhalm, G.; Rössler, K.; Trattnig, S.; Bogner, W. High-Resolution Metabolic Imaging of High-Grade Gliomas Using 7T-CRT-FID-MRSI. NeuroImage Clin. 2020, 28, 102433. https://doi.org/10.1016/j.nicl.2020.102433 [doi]
3. 3) Hangel, G.; Lazen, P.; Cadrien, C.; Chambers, S.; Furtner, J.; Hingerl, L.; Strasser, B.; Kiesel, B.; Mischkulnig, M.; Preusser, M.; Roetzer-Pejrimovsky, T.; Wöhrer, A.; Bogner, W.; Rössler, K.; Trattnig, S.; Widhalm, G. High-Resolution Mapping of Tumor and Peritumoral Glutamate and Glutamine in Gliomas Using 7-T MRSI.
4. 4) Hangel, G. (2022, April 26). 7T HR FID-MRSI Compared to Amino Acid PET: Glutamine and Glycine as Promising Biomarkers in Brain Tumors. PubMed. Retrieved November 4, 2023, from https://pubmed.ncbi.nlm.nih.gov/35565293/ [pmid]
5. 5) Thomas, S.N.; French, D.; Jannetto, P.J.; Rappold, B.A.; Clarke, W.A. (2022). Liquid chromatography–tandem mass spectrometry for clinical diagnostics. Nat. Rev. Methods Prim., 2, 96.
6. 6) Beare, R. (2022, September 7). Karawun: a software package for assisting evaluation of advances in multimodal imaging for neurosurgical planning and intraoperative neuronavigation. NCBI. Retrieved November 8, 2023, from https://ncbi.nlm.nih.gov/pmc/articles/PMC9883338/
7. 7) Hingerl, L. (2020). Clinical High-Resolution 3D-MR Spectroscopic Imaging of the Human Brain at 7 T. PubMed. Retrieved November 7, 2023, from https://pubmed.ncbi.nlm.nih.gov/31855587/ [pmid]
8. 8) Bogner, W. (2011, December 22). High-resolution mapping of human brain metabolites by free induction decay (1H) MRSI at 7 T. PubMed. Retrieved November 5, 2023, from https://pubmed.ncbi.nlm.nih.gov/22190245/ [pmid]
9. 9) Louis, D. (2021, August 2). The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. PubMed. Retrieved November 3, 2023, from https://pubmed.ncbi.nlm.nih.gov/34185076/ [pmid]
10. 10) Kampa, J. (2019, March 9). Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH-mutated gliomas revealed by mass spectrometry imaging. Retrieved November 8, 2023, from https://onlinelibrary.wiley.com/doi/full/10.1111/neup.12671
11. 11) S. Acharya Quantitative validation of 7T MRSI in gliomas by targeted mass spectrometry (ISMRM abstract 2025). https://docs.google.com/document/d/1PGbonS5n3Aq_YwyRX2AiyjeyAqzb3CW5Ye994w6oxfY/edit?usp=sharing

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/470-11-160