Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
570-08-226 ISMRM Abstract

In Vivo MRI Reveals Melatonin Alleviates Hypoxic-Ischemic Brain Damage by Suppressing TXNIP/Trx-1/GPX4-Mediated Ferroptosis

Primary: Preclinical Animal & in vitro MR - Biology, Models, Methods
Secondary: Neuro - Stroke and Cerebrovascular Disorders
570-08-226 · Preclinical · Wednesday, 13 May, 4:00 PM–4:55 PM · Traditional Posters | Exhibition Hall
Keywords: Hypoxic-ischemic brain damage Melatonin Neonatal rats Ferroptosis Thioredoxin-interacting protein
Accepted
Xiaoli Wang1,2, Youcheng Qin1, Peilun Xiao3, Xinyue Zhang4, Xiaozu Zhang1, Haimo Zhang1,5, Yijing Wang1, Miao Yu1, Peng Wu 6
1School of Medical Imaging, Shandong Second Medical University, Weifang, China
2Medical Imaging Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China
3School of Basic Medicine, Shandong Second Medical University, Weifang, China
4Department of Radiology, The Zhengzhou Central Hospital Affiliated of Zhengzhou University, Zhengzhou, China
5Department of Medical Laboratory Animal Center, Shandong Second Medical University, Weifang, China
6Clinical & Technical Support, Philips Healthcare, Guangzhou, China
Presenting Author: Peng Wu

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References

1. Lin W, Zhang T, Zheng J, et al. Ferroptosis is involved in hypoxic-ischemic brain damage in neonatal rats. Neuroscience. 2022, 487:131–142. PMID:35182697 [pmid]
2. Bai L, Yan F, Deng R, et al. Thioredoxin-1 rescues MPP+/MPTP-induced ferroptosis by increasing glutathione peroxidase 4. Mol Neurobiol. 2021, 58(7):3187–3197. PMID:33634378 [pmid]
3. Nasoohi S, Ismael S, Ishrat T, et al. Thioredoxin-interacting protein (TXNIP) in cerebrovascular and neurodegenerative diseases: regulation and implication. Mol Neurobiol. 2018, 55(10):7900–7920. PMID:29488135 [pmid]
4. Lim JO, Lee SJ, Kim WI, et al. Melatonin alleviates silica nanoparticle-induced lung inflammation via thioredoxin-interacting protein downregulation. Antioxidants (Basel). 2021, 10(11):1765. PMID:34829636 [pmid]
5. Zhang D, Jia X, Lin D, et al. Melatonin and ferroptosis: mechanisms and therapeutic implications. Biochem Pharmacol. 2023, 218:115909. PMID:37931663 [pmid]
6. Lv QK, Tao KX, Yao XY, et al. Melatonin MT1 receptors regulate the Sirt1/Nrf2/HO-1/GPX4 pathway to prevent α-synuclein-induced ferroptosis in Parkinson’s disease. J Pineal Res. 2024, 76(2):e12948. PMID:38488331 [pmid]
7. Ren C, Tan P, Gao L, et al. Melatonin reduces radiation-induced ferroptosis in hippocampal neurons by activating the PKM2/NRF2/GPX4 signaling pathway. Prog Neuropsychopharmacol Biol Psychiatry. 2023, 126:110777. PMID:37100272 [pmid]
8. Xiong Q, Li X, Xia L, et al. Dihydroartemisinin attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting oxidative stress. Mol Brain. 2022, 15(1):36. PMID:35484595 [pmid]
9. Tsubaki H, Tooyama I, Walker DG, et al. Thioredoxin-interacting protein (TXNIP) with focus on brain and neurodegenerative diseases. Int J Mol Sci. 2020, 21(24):9357. PMID:33302545 [pmid]
10. Arnautovic T, Sinha S, Laptook AR, et al. Neonatal hypoxic-ischemic encephalopathy and hypothermia treatment. Obstet Gynecol. 2024, 143(1):67–81. PMID:37797337 [pmid]

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http://echo.ismrm.org/p/ISMRM2026/570-08-226