Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
604-02-002 ISMRM Abstract

Cerebral hemodynamics in white matter lesions and their penumbra in older adults using 7T arterial spin labeling MRI

Accepted
Jan A Kufer 1,2, Hannah C Weibley3, Theodora Martin3, Marta Vidorreta4, John Detre5,6, Yulin Chang7, Jason Stockmann3,8, Meher R Juttukonda3,8
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, United States of America
2Department of Radiology, Harvard Medical School, Boston, United States of America
3Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
4Siemens Healthcare, Madrid, Spain
5Department of Neurology, University of Pennsylvania, Philadelphia, United States of America
6University of Pennsylvania, Philadelphia, United States of America
7Siemens Medical Solutions USA, Inc., Malvern, United States of America
8Harvard Medical School, Boston, United States of America
Presenting Author: Jan A Kufer

Synopsis

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References

1. 1. Wardlaw, J. M., Smith, E. E., Biessels, G. J., Cordonnier, C., Fazekas, F., Frayne, R., Lindley, R. I., O’brien, J. T., Barkhof, F., Benavente, O. R., Black, S. E., Brayne, C., Breteler, M., Chabriat, H., Decarli, C., De Leeuw, F.-E., Doubal, F., Duering, M., Fox, N. C., … Dichgans, M. (2013). Position Paper Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. In www.thelancet.com/neurology (Vol. 12). www.thelancet.com/neurology
2. 2. Ten Dam, V. H., Van Den Heuvel, D. M. J., De Craen, A. J. M., Bollen, E. L. E. M., Murray, H. M., Westendorp, R. G. J., Blauw, G. J., & Van Buchem, M. A. (2007). Decline in total cerebral blood flow is linked with increase in periventricular but not deep white matter hyperintensities. Radiology, 243(1), 198–203. https://doi.org/10.1148/radiol.2431052111 [doi]
3. 3. Van Dalen, J. W., Mutsaerts, H. J. M. M., Nederveen, A. J., Vrenken, H., Steenwijk, M. D., Caan, M. W. A., Majoie, C. B. L. M., Van Gool, W. A., & Richard, E. (2016). White matter hyperintensity volume and cerebral perfusion in older individuals with hypertension using arterial spin-labeling. American Journal of Neuroradiology, 37(10), 1824–1830. https://doi.org/10.3174/ajnr.A4828 [doi]
4. 4. Promjunyakul, N. O., Lahna, D. L., Kaye, J. A., Dodge, H. H., Erten-Lyons, D., Rooney, W. D., & Silbert, L. C. (2016). Comparison of cerebral blood flow and structural penumbras in relation to white matter hyperintensities: A multi-modal magnetic resonance imaging study. Journal of Cerebral Blood Flow and Metabolism, 36(9), 1528–1536. https://doi.org/10.1177/0271678X16651268 [doi]
5. 5. Promjunyakul, N., Lahna, D., Kaye, J. A., Dodge, H. H., Erten-Lyons, D., Rooney, W. D., & Silbert, L. C. (2015). Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures. NeuroImage: Clinical, 8, 224–229. https://doi.org/10.1016/j.nicl.2015.04.012 [doi]
6. 6. Alsop, D. C., Detre, J. A., Golay, X., Günther, M., Hendrikse, J., Hernandez-Garcia, L., Lu, H., Macintosh, B. J., Parkes, L. M., Smits, M., Van Osch, M. J. P., Wang, D. J. J., Wong, E. C., & Zaharchuk, G. (2015). Recommended implementation of arterial spin-labeled Perfusion mri for clinical applications: A consensus of the ISMRM Perfusion Study group and the European consortium for ASL in dementia. Magnetic Resonance in Medicine, 73(1), 102–116. https://doi.org/10.1002/mrm.25197 [doi]
7. 7. Teeuwisse, W. M., Webb, A. G., & Van Osch, M. J. P. (2010). Arterial spin labeling at ultra-high field: All that glitters is not gold. International Journal of Imaging Systems and Technology, 20(1), 62–70. https://doi.org/10.1002/ima.20218 [doi]
8. 8. Saïb, G., Koretsky, A. P., & Talagala, S. L. (2022). Optimization of pseudo-continuous arterial spin labeling using off-resonance compensation strategies at 7T. Magnetic Resonance in Medicine, 87(4), 1720–1730. https://doi.org/10.1002/mrm.29070 [doi]
9. 9. Ji, Y., Woods, J. G., Li, H., & Okell, T. W. (2025). Dynamic B0 field shimming for improving pseudo-continuous arterial spin labeling at 7 T. Magnetic Resonance in Medicine, 93(4), 1674–1689. https://doi.org/10.1002/mrm.30387 [doi]
10. 10. Woods, J. G., Ji, Y., Li, H., Hess, A. T., & Okell, T. W. (2025). SNR-efficient whole-brain pseudo-continuous arterial spin labeling perfusion imaging at 7 T. Magnetic Resonance in Medicine, 94(3), 965–981. https://doi.org/10.1002/mrm.30527 [doi]
11. 11. Luh, W. M., Talagala, S. L., Li, T. Q., & Bandettini, P. A. (2013). Pseudo-continuous arterial spin labeling at 7 T for human brain: Estimation and correction for off-resonance effects using a Prescan. Magnetic Resonance in Medicine, 69(2), 402–410. https://doi.org/10.1002/mrm.24266 [doi]
12. 12. Chappell, M. A., Kirk, T. F., Craig, M. S., McConnell, F. A. K., Zhao, M. Y., MacIntosh, B. J., Okell, T. W., & Woolrich, M. W. (2023). BASIL: A toolbox for perfusion quantification using arterial spin labelling. Imaging Neuroscience, 1, 1–16. https://doi.org/10.1162/imag_a_00041 [doi]
13. 13. Dolui, S., Tisdall, D., Vidorreta, M., Jacobs, D. R., Nasrallah, I. M., Bryan, R. N., Wolk, D. A., & Detre, J. A. (2019). Characterizing a perfusion-based periventricular small vessel region of interest. NeuroImage: Clinical, 23. https://doi.org/10.1016/j.nicl.2019.101897 [doi]

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