Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
331-01-015 / 331-01-015 ISMRM Abstract

Dynamic ¹H MRS at 11.7 T Reveals Minute-Scale Neurochemical Kinetics in Mouse Caudate–Putamen after Lactate Challenge

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Preclinical Animal & in vitro MR - Small Animals
331-01-015 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
331-01-015 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
Keywords: Single voxel spectroscopy Lactate In vivo proton magnetic resonance spectroscopy Animal mouse model Caudate-putamen
Accepted
Alireza Abaei 1, Dinesh K Deelchand2, Francesco Roselli3, Volker Rasche4
1Core Facility for Small Animal Imaging, Medical Faculty, Ulm University, Ulm, Germany
2University of Minnesota, CMRR, United States of America
3German Center for Neurodegenerative Diseases (DZNE) Ulm, Ulm, Germany
4Internal Medicine II, Ulm University, Medical Center, Ulm, Germany
Presenting Author: Alireza Abaei

Synopsis

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References

1. Andersen JV. The Glutamate/GABA-Glutamine Cycle: Insights, Updates, and Advances. J Neurochem. 2025 Mar;169(3):e70029. doi: 10.1111/jnc.70029 [doi]
2. Andersen JV, Schousboe A. Milestone Review: Metabolic dynamics of glutamate and GABA mediated neurotransmission - The essential roles of astrocytes. J Neurochem. 2023 Jul;166(2):109-137. doi: 10.1111/jnc.15811. [doi]
3. Drew PJ, Mateo C, Turner KL, Yu X, Kleinfeld D. Ultra-slow oscillations in fMRI and resting-state connectivity: neuronal and vascular contributions and technical confounds. Neuron. 2020.
4. Arecco N, Roselli F, et al. Energy metabolites and basal ganglia dysfunction. Journal of Neuroscience Research. 2024.
5. Crespy T, Durost M, Fricault P, Lemasson B, Bouzat P, Barbier EL, Payen JF. Hypertonic Sodium Lactate to Alleviate Functional Deficits Following Diffuse Traumatic Brain Injury: An Osmotic or a Lactate-Related Effect? Neurocrit Care. 2021 Jun;34(3):795-803.
6. Garwood, M. & DelaBarre, L. The return of the frequency sweep: designing adiabatic pulses for contemporary NMR. J MagnReson 153, 155-177, (2001).
7. http://www.cmrr.umn.edu/downloads/mrspa

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/331-01-015