Synopsis
Motivation:
Goals:
Approach:
Results:
470-05-113
ISMRM Abstract
Relating Diffusion MRI-Derived Axon Diameters to the Underlying Diameter Distribution
Accepted
Full abstract & presentation
The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.
Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.
To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.
Log inReferences
1. Veraart J, Nunes D, Rudrapatna U, Fieremans E, Jones DK, Novikov DS, Shemesh N (2020) Noninvasive quantification of axon radii using diffusion MRI. eLife 9:e49855. https://doi.org/10.7554/eLife.49855 [doi]
2. Burcaw LM, Fieremans E, Novikov DS (2015) Mesoscopic structure of neuronal tracts from time-dependent diffusion. NeuroImage 114:18–37. https://doi.org/10.1016/j.neuroimage.2015.03.061 [doi]
3. Alexander DC, Hubbard PL, Hall MG, Moore EA, Ptito M, Parker GJM, Dyrby TB (2010) Orientationally invariant indices of axon diameter and density from diffusion MRI. Neuroimage 52(4):1374–1389. https://doi.org/10.1016/j.neuroimage.2010.05.043 [doi]
4. Dyrby TB, Sogaard LV, Hall MG, Ptito M, Alexander DC (2013) Contrast and stability of the axon diameter index from microstructure imaging with diffusion MRI. Magn Reson Med 70(3):711–721. https://doi.org/10.1002/mrm.24501 [doi]
5. Neuman CH (1974) Spin echo of spins diffusing in a bounded medium. J Chem Phys 60(11):4508–4511. https://doi.org/10.1063/1.1680931 [doi]
6. Andersson M, Kjer HM, Rafael-Patino J, Pacureanu A, Pakkenberg B, Thiran J-P, Ptito M, Bech M, Bjorholm Dahl A, Andersen Dahl V, Dyrby TB (2020) Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure–function relationship. Proc Natl Acad Sci USA 117(52):33649–33659. https://doi.org/10.1073/pnas.2012533117 [doi]
7. Mordhorst L, Edwards L, Morozova M, Ashtarey M, Streubel T, Fricke B, … Mohammadi S (2025) Towards MRI axon radius mapping in clinical settings: insights from MRI-scale histology and experimental validation.
8. Andersson M, Pizzolato M, Kjer HM, Skodborg KF, Lundell H, Dyrby TB (2022) Does powder averaging remove dispersion bias in diffusion MRI diameter estimates within real 3D axonal architectures? NeuroImage 248:118718. https://doi.org/10.1016/j.neuroimage.2021.118718 [doi]
9. Canales-Rodríguez E, Pizzolato M, Zhou F, Baraković M, Thiran J-P, Jones DK, Parker GJ, Dyrby TB (2024) Pore size estimation in axon-mimicking microfibers with diffusion–relaxation MRI. Magnetic Resonance in Medicine 91. https://doi.org/10.1002/mrm.29991 [doi]
10. Nilsson M, Lasič S, Drobnjak I, Topgaard D, Westin CF (2017) Resolution limit of cylinder diameter estimation by diffusion MRI: The impact of gradient waveform and orientation dispersion. NMR Biomed 30(7):e3711. https://doi.org/10.1002/nbm.3711 [doi]
11. Skoven CS, Andersson M, Barquin Torre ML, Pizzolato M, Siebner HR, Dyrby TB (2025) Axonal structure–function relationships across experimental modalities. Imaging Neuroscience.
12. van Gelderen P, Despres D, van Zijl PC, Moonen CT (1994) Evaluation of restricted diffusion in cylinders: phosphocreatine in rabbit leg muscle. J Magn Reson B 103:255–260. https://doi.org/10.1006/jmrb.1994.1038 [doi]
13. Pedregosa F, Varoquaux G, Gramfort A, Michel V, Thirion B, Grisel O, Blondel M, Prettenhofer P, Weiss R, Dubourg V, Vanderplas J, Passos A, Cournapeau D, Brucher M, Perrot M, Duchesnay E (2011) Scikit-learn: Machine learning in Python. Journal of Machine Learning Research 12:2825–283 http://jmlr.csail.mit.edu/papers/v12/pedregosa11a.html
Cite this abstract
http://echo.ismrm.org/p/ISMRM2026/470-05-113