Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
368-02-007 ISMRM Abstract

Comprehensive Quantitative MRI Biomarker Platform for Knee Osteoarthritis: Technical Validation and Multi-Reader Reliability

Primary: Musculoskeletal - Osteoarthritis
Secondary: Analysis Methods - Segmentation and Detection
368-02-007 · Segmentation for Musculoskeletal MRI Applications · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row I
Keywords: Analysis/Processing Joints Precision & Accuracy Tissue Characterization Validation
Accepted
Greg Gilles 1, Dagoberto Robles1, Nathaniel H Christiansen1, Karim Jayyusi1, Ali Shaikh1, Rongrong Tang1, Mihra S Taljanovic1,2,3, Jeffrey Duryea4, Edward J Bedrick5, C. Kent Kwoh1
1College of Medicine, Arthritis Center, University of Arizona, Tucson, United States of America
2Departments of Medical Imaging and Orthopaedic Surgery, University of Arizona, Tucson, United States of America
3Department of Radiology, University of New Mexico Health Sciences, Albuquerque, United States of America
4Brigham and Women's Hospital and Harvard Medical School, Boston, United States of America
5University of Arizona Mel and Enid Zuckerman College of Public Health, Tucson, United States of America
Presenting Author: Greg Gilles

Synopsis

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References

1. GBD 2021 Osteoarthritis Collaborators. Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5(9):e508-e522. Published 2023 Aug 21. doi:10.1016/S2665-9913(23)00163-7 [doi]
2. Sharma L. Osteoarthritis of the Knee. N Engl J Med. 2021;384(1):51-59. doi:10.1056/NEJMcp1903768 [doi]
3. Long H, Liu Q, Yin H, et al. Prevalence Trends of Site-Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019. Arthritis Rheumatol. 2022;74(7):1172-1183. doi:10.1002/art.42089 [doi]
4. Katz JN, Arant KR, Loeser RF. Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review. JAMA. 2021;325(6):568-578. doi:10.1001/jama.2020.22171 [doi]
5. Leifer VP, Katz JN, Losina E. The burden of OA-health services and economics. Osteoarthritis Cartilage. 2022;30(1):10-16. doi:10.1016/j.joca.2021.05.007 [doi]
6. Thirumaran AJ, Deveza LA, Atukorala I, Hunter DJ. Assessment of Pain in Osteoarthritis of the Knee. J Pers Med. 2023;13(7):1139. Published 2023 Jul 14. doi:10.3390/jpm13071139 [doi]
7. Oo WM, Little C, Duong V, Hunter DJ. The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date. Drug Des Devel Ther. 2021;15:2921-2945. Published 2021 Jul 6. doi:10.2147/DDDT.S295224 [doi]
8. Walsh DA, Sofat N, Guermazi A, Hunter DJ. Osteoarthritis Bone Marrow Lesions. Osteoarthritis Cartilage. 2023;31(1):11-17. doi:10.1016/j.joca.2022.09.007 [doi]
9. Ramezanpour S, Kanthawang T, Lynch J, et al. Impact of Sustained Synovitis on Knee Joint Structural Degeneration: 4-Year MRI Data from the Osteoarthritis Initiative. J Magn Reson Imaging. 2023;57(1):153-164. doi:10.1002/jmri.28223 [doi]
10. Smith SE, Hosseinzadeh S, Maetani T, et al. Association of quantitative measures of effusion-synovitis and hoffa-synovitis with radiographic and pain progression: Data from the FNIH OA biomarkers consortium. Osteoarthr Cartil Open. 2021;3(1):100138. Published 2021 Jan 11. doi:10.1016/j.ocarto.2021.100138 [doi]
11. Gilles G, Robles D, Grawer L, et al. Reliability and Validity of Novel Multi-View, Whole-Knee Effusion-Synovitis Quantification with Axial and Sagittal Segmentation on 3T Knee MRI. ISMRM; 2025:4681.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/368-02-007