552-01-006 / 552-01-006 ISMRM Abstract

Myocardial Energetics in Hypertrophic Cardiomyopathy: ³¹P-MRS Reveals Phenotypic Insights and Mechanical Performance

Primary: Cardiovascular - Myocardium

Secondary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging

552-01-006 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2

Keywords: Phosphorous Magnetic Resonance Spectroscopy Hypertrophic cardiomyopathy Myocardial strain Cardiovascular magnetic resonance Cardiac energetics

Accepted

Yifan Dong ¹, Wenjing Yang¹, jianxiu lian², Dandan Zheng², Minjie Lu¹

¹Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

²Philips Healthcare (Beijing), Beijing, China

Presenting Author: Yifan Dong

Synopsis

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References

1. Crilley JG, Boehm EA, Blair E, Rajagopalan B, Blamire AM, Styles P, McKenna WJ, Ostman-Smith I, Clarke K, Watkins H. Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy. J Am Coll Cardiol. 2003 May 21;41(10):1776-82. doi: 10.1016/s0735-1097(02)03009-7. PMID: 12767664. [doi] [pmid]

2. Shivu GN, Abozguia K, Phan TT, Ahmed I, Henning A, Frenneaux M. (31)P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy: Experiences at 3T. Eur J Radiol. 2010 Feb;73(2):255-9. doi: 10.1016/j.ejrad.2008.10.018. Epub 2008 Dec 3. PMID: 19056193. [doi] [pmid]

3. Dass S, Cochlin LE, Suttie JJ, Holloway CJ, Rider OJ, Carden L, Tyler DJ, Karamitsos TD, Clarke K, Neubauer S, Watkins H. Exacerbation of cardiac energetic impairment during exercise in hypertrophic cardiomyopathy: a potential mechanism for diastolic dysfunction. Eur Heart J. 2015 Jun 21;36(24):1547-54. doi: 10.1093/eurheartj/ehv120. Epub 2015 May 18. PMID: 25990345. [doi] [pmid]

4. Z Ashkir, A Abd Samat, L Finnigan, M A Ahktar, N Beyhoff, R Sarwar, E Wicks, O Rider, L Valkovic, M Mahmod, H Watkins, S Neubauer, B Raman, Impaired myocardial energetics in both sarcomere positive and negative HCM are linked to arrhythmic risk, European Heart Journal, Volume 45, Issue Supplement_1, October 2024, ehae666.2054, https://doi.org/10.1093/eurheartj/ehae666.2054 [doi]

5. Ormerod JO, Frenneaux MP, Sherrid MV. Myocardial energy depletion and dynamic systolic dysfunction in hypertrophic cardiomyopathy. Nat Rev Cardiol. 2016 Nov;13(11):677-687. doi: 10.1038/nrcardio.2016.98. Epub 2016 Jul 14. PMID: 27411403. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/552-01-006