468-01-008 ISMRM Abstract

Trial-Ready Power Estimates for Longitudinal Resting-state fMRI Biomarkers in ALS

Primary: Brain Function and fMRI - Functional Connectivity

Secondary: Neuro - Other Neurodegeneration

468-01-008 · Quantitative Neuroimaging of Neurodegeneration, Metabolism, and Brain Microstructure · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row I

Keywords: Amyotrophic lateral sclerosis Biomarker estimation Clinical trials Resting-state functional MRI Multi-center study

Accepted

Pedram Parnianpour¹, Sanjay Kalra², Erik P Pioro ¹

¹Medicine (Neurology), Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada

²Division of Neurology, Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada

Presenting Author: Erik P Pioro

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References

1. Kalra S, Khan M, Barlow L, et al. The Canadian ALS Neuroimaging Consortium (CALSNIC)-a multicentre platform for standardized imaging and clinical studies in ALS. medRxiv. Published online July 2020:2020.07.10.20142679. doi:10.1101/2020.07.10.20142679 [doi]

2. Esteban O, Markiewicz CJ, Blair RW, et al. fMRIPrep: a robust preprocessing pipeline for functional MRI. Nat Methods. 2019;16(1):111-116. doi:10.1038/s41592-018-0235-4 [doi]

3. Mehta K, Salo T, Madison T, et al. XCP-D: A Robust Pipeline for the post-processing of fMRI data. doi:10.1101/2023.11.20.567926 [doi]

4. Müller HP, Abrahao A, Beaulieu C, et al. Temporal and spatial progression of microstructural cerebral degeneration in ALS: A multicentre longitudinal diffusion tensor imaging study. NeuroImage Clin. 2024;43:103633. doi:10.1016/j.nicl.2024.103633 [doi]

5. Ta D, Ishaque A, Srivastava O, et al. Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis: A Prospective Multicenter Study. Neurology. 2021;97(8). doi:10.1212/WNL.0000000000012367 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/468-01-008