406-01-009 ISMRM Abstract

Pressure Waves and Phase Locks: Revealing Brain-CSF coupling mechanisms with Single-Slice Ultrafast fMRI

Primary: Brain Function and fMRI - fMRI Analysis

Secondary: Brain Function and fMRI - Functional Connectivity

406-01-009 · fMRI: Acquisition and Preprocessing · Tuesday, 12 May, 8:20 AM–10:10 AM · Auditorium 2

Keywords: Cerebrospinal fluid flow Resting-state fMRI Intracranial pressure waves GBOLD-CSF coupling

Accepted

Joana Cabral ¹

¹Institute for Systems and Robotics – Lisboa and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal

Presenting Author: Joana Cabral

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References

1. Han F, Chen J, Belkin-Rosen A, Gu Y, Luo L, Buxton RB, et al. (2021) Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease–related pathology. PLOS Biology 19(6): e3001233. https://doi.org/10.1371/journal.pbio.3001233 [doi]

2. Wang Z, Song Z, Zhou C, et al. Reduced coupling of global brain function and cerebrospinal fluid dynamics in Parkinson’s disease. Journal of Cerebral Blood Flow & Metabolism. 2023;43(8):1328-1339. doi:10.1177/0271678X231164337 [doi]

3. Qian R, Wang L, Fan S, Xu X, Yu Y, Qi L, et al. (2025) Reduced coupling between global signal and cerebrospinal fluid inflow in patients with generalized anxiety disorder: A resting state functional MRI study. Journal of Affective Disorders. https://doi.org/10.1016/j.jad.2025.119851 [doi]

4. Botta D, Hutuca I, El Ghoul E, Sveikata L, Assal F, Lövblad KO, et al. (2025) Emerging non-invasive MRI techniques for glymphatic system assessment in neurodegenerative disease. Journal of Neuroradiology. https://doi.org/10.1016/j.neurad.2025.101322 [doi]

5. Cabral, J., Fernandes, F.F. & Shemesh, N. Intrinsic macroscale oscillatory modes driving long range functional connectivity in female rat brains detected by ultrafast fMRI. Nature Communications 14, 375 (2023). https://doi.org/10.1038/s41467-023-36025-x [doi]

6. Gonçalves, I., Oliveira, D., Rocha, C. et al. Brain modes of resonance estimated by a biophysical multi-compartment finite elements model. Sci Rep 15, 33845 (2025). https://doi.org/10.1038/s41598-025-00938-y [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/406-01-009