Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
668-01-001 ISMRM Abstract

Cerebral Bioenergetic Responses to Hyperglycemia: Linking Glucose Uptake and Phosphate Energy Metabolism in the Human Brain

Primary: Contrast Mechanisms - Molecular Imaging
Secondary: Contrast Mechanisms - Multi-Contrast
668-01-001 · Molecular Imaging and Ultra High Field Acquisition · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row I
Keywords: Diabetes Energy metabolism Phosphorus Functional MRI Hyperglycemia
Accepted
Mark Widmaier 1, Brooke C Matson2, uzay emir3,4,5,6, Janice J Hwang2
1Radiology, University of North Carolina, Chapel Hill, United States of America
2Department of Medicine, University of North Carolina, Chapel Hill, United States of America
3University of North Carolina at Chapel Hill, Chapel Hill, United States of America
4Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
5Lampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
6Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
Presenting Author: Mark Widmaier

Synopsis

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References

1. Hwang, J.J., et al., Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. JCI Insight, 2017. PMID: 29046482; DOI:10.1172/jci.insight.95913 [doi] [pmid]
2. Gunawan, F., et al., Deficits in brain glucose transport among younger adults with obesity. Obesity (Silver Spring), 2024. 32(7): p. 1329–1338. DOI: 10.1002/oby.24034 [doi]
3. Tkac, I., et al., In vivo 1H NMR spectroscopy of the human brain at 7 T. Magn Reson Med, 2001. 46(3): p. 451–6. PMID: 11550235; DOI: 10.1002/mrm.1213 [doi] [pmid]
4. Emir, U.E., et al., Regional neurochemical profiles in the human brain measured by (1)H MRS at 7 T using local B(1) shimming. NMR Biomed, 2012. 25(1): p. 152–60. PMID: 21766380; DOI: 10.1002/nbm.1727 [doi] [pmid]
5. Shen, X., et al., 3D balanced SSFP UTE MRI for multiple contrasts whole brain imaging. Magn Reson Med, 2024. 92(2): p. 702–714. PMID: 38525680; DOI: 10.1002/mrm.30093 [doi] [pmid]
6. Shen, X., et al., Ultra-short T(2) components imaging of the whole brain using 3D dual-echo UTE MRI with rosette k-space pattern. Magn Reson Med, 2023. 89(2): p. 508–521. PMID: 36161728; DOI: 10.1002/mrm.29451 [doi] [pmid]
7. Bozymski B, et al., 3D ultra-short echo time 31P-MRSI with rosette k-space pattern: Feasibility and comparison with conventional weighted CSI. Sci Rep. 2025 Feb 22;15(1):6465. PMID: 38659806 DOI: 10.21203/rs.3.rs-4223790/v1 [doi] [pmid]
8. Alcicek S, et al., Multi-site feasibility and reproducibility study on UTE 3D phosphorous MRSI using novel rosette trajectory (PETALUTE). Magn Reson Med. 2025 Dec;94(6):2324-2334. PMID: 40692528; doi: 10.1002/mrm.30640. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/668-01-001