Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-05-010 ISMRM Abstract

Quantitative evaluation of dynamic glymphatic activity in insomnia: A contrast-enhanced synthetic MRI study

Primary: Neuro - Gray Matter
Secondary: Acquisition & Reconstruction - Quantitative Imaging: relaxometry, multi-parametric, MR Fingerprinting, and synthetic MRI
460-05-010 · When Brain Clearance Fails: Glymphatic Dysfunction Across Disorders · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row A
Keywords: MR Fingerprinting/Synthetic MR Sleep Glymphatic system Insomnia
Accepted
Ruifang Xiong 1, Jiankun Dai2, Ye Wang3, Qingqing Wen2, Xiaoping Tang1
1Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
2MR Research, Beijing, China
3The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
Presenting Author: Ruifang Xiong

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References

1. Hertenstein E, Feige B, Gmeiner T, et al. Insomnia as a predictor of mental disorders: a systematic review and meta-analysis. Sleep Med Rev. 2019;43:96–105. https://doi.org/10.1016/j.smrv.2018.10.006 [doi]
2. Lee S, Yoo RE, Choi SH, et al. Contrast-enhanced MRI T1 mapping for quantitative evaluation of putative dynamic glymphatic activity in the human brain in sleep-wake states. Radiology. 2021;300(3):661–8. https://doi.org/10.1148/radiol.2021203784 [doi]
3. Zheng X, Zhang Z, Liang X, et al. Application of DTI-ALPS index for the analysis of the function of central glymphatic system in patients with chronic insomnia. Radiologic Practice. 2023;38(12):1508-12. DOI: 10.13609/j.cnki.1000-0313.2023.12.003. [doi]
4. Jin Y, Zhang W, Yu M, et al. Glymphatic system dysfunction in middle-aged and elderly chronic insomnia patients with cognitive impairment evidenced by diffusion tensor imaging along the perivascular space (DTI-ALPS). Sleep Med. 2024; 115:145–51. https://doi.org/10.1016/j.sleep.2024.01.028 [doi]
5. Ringstad G. Glymphatic imaging: a critical look at the DTI-ALPS index. Neuroradiology. 2024;66(2):157–60. https://doi.org/10.1007/s00234-023-03270-2 [doi]
6. Iliff JJ, Lee H, Yu M, et al. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Investig. 2013;123(3):1299–309. doi:10.1172/JCI67677. [doi]
7. Jost G, Frenzel T, Naganawa S, et al. Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue. Eur Radiol. 2017;27(7):2877–85. https://doi.org/10.1007/s00330-016-4654-2 [doi]

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http://echo.ismrm.org/p/ISMRM2026/460-05-010