666-03-008 ISMRM Abstract

Whole-brain multiparametric MRI reveals cerebellar microstructural alterations in Atad5 knockout mice

Primary: Neuro - Other Neurodegeneration

Secondary: Preclinical Animal & in vitro MR - Biomarkers

666-03-008 · Neuro-Biomarkers · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row G

Keywords: Myelin water imaging Diffusion Tensor Imaging (DTI) Ex-vivo brain imaging Multiparametric quantitative MRI Deformation-based Morphometry

Accepted

Seokha Jin ¹, Eun-Sun Kim², shim junghoon¹, Shinseog Kim², Kyungjae Myung², HyungJoon Cho¹

¹Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of

²Center for Genomic Integrity, Institute for Basic Science (IBS), Korea, Republic of

Presenting Author: Seokha Jin

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References

1. Morimoto M, Ryu E, Steger BJ, et al. Expanding the genetic and phenotypic landscape of replication factor C complex-related disorders: RFC4 deficiency is linked to a multisystemic disorder. Am J Hum Genet. 2024;111(9):1970-1993. doi:10.1016/j.ajhg.2024.07.008 [doi]

2. Lee Y, Katyal S, Li Y, et al. The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat Neurosci. 2009;12(8):973-980. doi:10.1038/nn.2375 [doi]

3. Gaser C, Nenadic I, Buchsbaum BR, Hazlett EA, Buchsbaum MS. Deformation-based morphometry and its relation to conventional volumetry of brain lateral ventricles in MRI. Neuroimage. 2001;13(6 Pt 1):1140-1145. doi:10.1006/nimg.2001.0771 [doi]

4. MacKay A, Whittall K, Adler J, Li D, Paty D, Graeb D. In vivo visualization of myelin water in brain by magnetic resonance. Magn Reson Med. 1994;31(6):673-677. doi:10.1002/mrm.1910310614 [doi]

5. Le Bihan D, Mangin JF, Poupon C, et al. Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging. 2001;13(4):534-546. doi:10.1002/jmri.1076 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-03-008