Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
560-05-016 ISMRM Abstract

T2-anisotropy in Ex Vivo White Matter Described by the Transient Hydrogen Bond Model

Primary: Contrast Mechanisms - Microstructure
Secondary: Contrast Mechanisms - Relaxometry
560-05-016 · Acquisition Strategies Across Organs and Field Strengths · Wednesday, 13 May, 4:00 PM–4:55 PM · Digital Posters Row A
Keywords: Relaxometry White Matter Anisotropy Orientaion-dependent transverse relaxation Transient Hydrogen Bond model
Accepted
Niklas Wallstein 1,2, Andre Pampel2, Alexander L Sukstanskii3, Carsten Jäger4,5, Roland Müller2, Guillaume Duhamel1, Dmitriy Yablonskiy3, Harald E Möller2,6
1Aix Marseille Univ, Marseille, France
2NMR Methods & Development Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
3Department of Radiology, Washington University in St. Louis, St. Louis, United States of America
4Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
5Center of Neuropathology and Brain Research, Medical Faculty, University of Leipzig, Paul Flechsig Institute, Leipzig, Germany
6Felix Bloch Institute for Solid State Physics, Leipzig University, Germany
Presenting Author: Niklas Wallstein

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References

1. Kauppinen, R. A., et al. Fiber orientation‐dependent T1 angular features in human white matter at 1.5 T, 3 T, and 7 T. Magn. Reson. Med. (2025). doi:10.1002/mrm.70009 [doi]
2. Wallstein, N., et al. Anisotropic longitudinal water proton relaxation in white matter investigated ex vivo in porcine spinal cord with sample rotation. Sci. Rep. 14.1 (2024): 12961. Doi:10.1038/s41598-024-63483-0 [doi]
3. Pang, Y. Orientation dependent proton transverse relaxation in human brain white matter: The magic angle effect on a cylindrical helix. Magn. Reson. Imag. (2023): 100, 73-83. Doi:10.1016/j.mri.2023.03.010 [doi]
4. Bartels, L. M., et al. Orientation dependence of R2 relaxation in the newborn brain. NeuroImage 264 (2022): 119702. Doi:10.1016/j.neuroimage.2022.119702 [doi]
5. Birkl, C., et al. Myelin water imaging depends on white matter fiber orientation in the human brain. Magn. Reson. Med. 85.4 (2021): 2221-2231. Doi:10.1002/mrm.28543 [doi]
6. Aggarwal, M., et al. B0‐orientation dependent magnetic susceptibility‐induced white matter contrast in the human brainstem at 11.7 T. Magn. Reson. Med. (2016): 75(6), 2455-2463. Doi:10.1002/mrm.26208 [doi]
7. Sandgaard, A. D., et al. Investigating time-and orientation-dependent transverse relaxation from magnetic susceptibility of white matter microstructure. arXiv preprint arXiv:2509.26267 (2025).
8. Oh, S.-H., et al. Origin of B0 orientation dependent R2*(= 1/T2*) in white matter. Neuroimage 73 (2013): 71-79. Doi:10.1016/j.neuroimage.2013.01.051 [doi]
9. Knight, M. J., et al. Magnetic resonance relaxation anisotropy: Physical principles and uses in microstructure imaging. Biophysical journal 112.7 (2017): 1517-1528.
10. Wallstein, N., et al. Radiation damping at clinical field strength: Characterization and compensation in quantitative measurements. Magn. Reson. Med. 91.3 (2024): 1239-1253. Doi:10.1002/mrm.29934 [doi]
11. Pampel, A., et al. Investigations of T2 anisotropy in ex vivo WM using direct sample reorientation. Proceedings of the 33rd Annual Meeting of ISMRM, Honolulu, HI, USA, 2025.
12. Yablonskiy, D. A., and Sukstanskii, A. L. Quantum magnetization exchange through transient hydrogen bond matrix defines magnetic resonance signal relaxation and anisotropy in central nervous system. Sci. Rep. 15.1 (2025): 23834. Doi:10.1038/s41598-025-07808-7 [doi]
13. Yablonskiy, D. A., and Sukstanskii, A. L. Quantum dipole interactions and transient hydrogen bond orientation order in cells, cellular membranes and myelin sheath: Implications for MRI signal relaxation, anisotropy, and T1 magnetic field dependence. Magn. Reson. Med. 91.6 (2024): 2597-2611. Doi:10.1002/mrm.29996 [doi]
14. Levitt, M. H., and Freeman, R. Compensation for pulse imperfections in NMR spin-echo experiments. JMR (1969) 43.1 (1981): 65-80. Doi:10.1016/0022-2364(81)90082-2 [doi]
15. Poon, C. S., and Henkelman, R. M. Practical T2 quantitation for clinical applications. Journal of Magnetic Resonance Imaging 2.5 (1992): 541-553. Doi:10.1002/jmri.1880020512 [doi]

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http://echo.ismrm.org/p/ISMRM2026/560-05-016