Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026
· Cape Town, South Africa
468-01-009
ISMRM Abstract
MRI-Derived OEF and BBB Permeability Correlate with Neurological Severity in Wilson’s Disease
Primary:
Neuro - Other Neurodegeneration
Secondary:
Cross-Organ
468-01-009 · Quantitative Neuroimaging of Neurodegeneration, Metabolism, and Brain Microstructure
· Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row I
Chuan Liu 1, Lingyun Liu2, Miao Lin2, Yunzhu Wu3, Zixuan Lin4, Shuyue Wang2, Yi Dong1
1Department of Medical Genetics and Center for Rare Diseases, Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical Translation, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3MR Research Collaboration Team, Shanghai, China
4College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China
Presenting Author: Chuan Liu
Synopsis
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1. Shribman S, Bocchetta M, Sudre CH, Acosta-Cabronero J, Burrows M, Cook P, Thomas DL, Gillett GT, Tsochatzis EA, Bandmann O, Rohrer JD, Warner TT. Neuroimaging correlates of brain injury in Wilson’s disease: a multimodal, whole-brain MRI study. Brain. 2022;145(1):263‑75. doi:10.1093/brain/awab274. PMID:34289020. [doi][pmid]
2. Członkowska A, Litwin T, Dusek P, Ferenci P, Lutsenko S, Medici V, Rybakowski JK, Weiss KH, Schilsky ML. Wilson disease. Nat Rev Dis Primers. 2018;4(1):21. doi:10.1038/s41572-018-0018-3. PMID:30190489. [doi][pmid]
3. Lin Z, Lim C, Jiang D, Soldan A, Pettigrew C, Oishi K, Zhu Y, Moghekar A, Liu P, Albert M, Lu H. Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: relationship to markers of vascular and Alzheimer’s pathology. Alzheimers Dement. 2023;19(2):569‑77. doi:10.1002/alz.12727. PMID:35791732. [doi][pmid]
4. Lin Z, Sur S, Soldan A, Pettigrew C, Miller M, Oishi K, Bilgel M, Moghekar A, Pillai JJ, Albert M, Lu H. Brain oxygen extraction by using MRI in older individuals: relationship to apolipoprotein E genotype and amyloid burden. Radiology. 2019;292(1):140‑8. doi:10.1148/radiol.2019182726. PMID:31012816. [doi][pmid]
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6. Lin Z, Sur S, Liu P, Li Y, Jiang D, Hou X, Darrow J, Pillai JJ, Yasar S, Rosenberg P, Albert M, Moghekar A, Lu H. Blood–brain barrier breakdown in relationship to Alzheimer and vascular disease. Ann Neurol. 2021;90(2):227‑38. doi:10.1002/ana.26134. PMID:34041783. [doi][pmid]
7. Edwards NC, Lao P, Alshikho MJ, Mazen J, Huber B, Hale C, Berroa J, Morel N, Pacheco A, Walker S, Herman M, Gutierrez J, Wilcock DM, Simoes S, Manly JJ, Brickman AM. Alzheimer disease, vascular disease, and blood–brain barrier permeability biomarkers in middle-aged adults. Neurology. 2025;105(9):e214220. doi:10.1212/WNL.0000000000214220. PMID:41052375. [doi][pmid]
8. Deng W, Zhang J, Yang J, Wang Z, Pan Z, Yue X, Zhao R, Qian Y, Yu Y, Li X. Changes in brain susceptibility in Wilson’s disease patients: a quantitative susceptibility mapping study. Clin Radiol. 2024;79(2):e282‑6. doi:10.1016/j.crad.2023.11.002. PMID:38087682. [doi][pmid]
9. Fan SP, Chen YF, Li CH, Kuo YC, Lee NC, Chien YH, Hwu WL, Tseng TC, Su TH, Hsu CT, Chen HL, Lin CH, Ni YH. Topographical metal burden correlates with brain atrophy and clinical severity in Wilson’s disease. Neuroimage. 2024;299:120829. doi:10.1016/j.neuroimage.2024.120829. PMID:39233127. [doi][pmid]
10. Fan SP, Chen YF, Li CH, Kuo YC, Lee NC, Chien YH, Hwu WL, Tseng TC, Su TH, Hsu CT, Chen HL, Lin CH, Ni YH. Plasma glial fibrillary acidic protein correlates with brain metal burden in Wilson’s disease. Ann Clin Transl Neurol. 2025. doi:10.1002/acn3.70177. PMID:40913012. [doi][pmid]
11. Dusek P, Bahn E, Litwin T, Jabłonka-Salach K, Łuciuk A, Huelnhagen T, Madai VI, Dieringer MA, Bulska E, Knauth M, Niendorf T, Sobesky J, Paul F, Schneider SA, Członkowska A, Brück W, Wegner C, Wuerfel J. Brain iron accumulation in Wilson disease: a post mortem 7 Tesla MRI–histopathological study. Neuropathol Appl Neurobiol. 2017;43(6):514‑32. doi:10.1111/nan.12341. PMID:27543917. [doi][pmid]