Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
463-04-006 ISMRM Abstract

Identifying differences in perivascular spaces and cortical thickness in traumatic brain injury at 7T

Primary: Neuro - Traumatic Brain Injury
Secondary: Neuro - Neurofluids
463-04-006 · Advanced Microstructural Imaging of White Matter and Traumatic Brain Injury · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row D
Keywords: Traumatic brain injury Cortical thickness 7 Tesla Perivascular spaces (PVS) Post-traumatic epilepsy
Accepted
Jacey J Auger 1, Jason A Reich1, Kristen Dams-O'Connor2,3,4, Gaurav Verma5,6, Bradley N Delman6, Madeline C Fields3, Lara V Marcuse3, Priti Balchandani5,6,7,8, Erin L MacMillan9,10, Rebecca E Feldman1,5,10
1Department of Computer Science, Mathematics, Physics and Statistics, University of British Columbia, Vancouver, Canada
2Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, United States of America
3Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, United States of America
4Brain Injury Research Centre, Icahn School of Medicine at Mount Sinai, New York, United States of America
5BioMedical Engineering and Imaging Institute (BMEII), Icahn School of Medicine at Mount Sinai, New York, United States of America
6Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, United States of America
7Neuroscience, Icahn School of Medicine at Mount Sinai, New York, United States of America
8Psychiatry, Icahn School of Medicine at Mount Sinai, New York, United States of America
9Department of Radiology, University of British Columbia, Vancouver, Canada
10UBC MRI Research Centre, University of British Columbia, Vancouver, Canada
Presenting Author: Jacey J Auger

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References

1. Ding K, Gupta PK, Diaz-Arrastia R. Epilepsy After Traumatic Brain Injury. In: Translational Research in Traumatic Brain Injury. CRC Press/Taylor and Francis Group; 2016:1-11. Accessed October 22, 2025. PMID: 26583175 [pmid]
2. Capizzi A, Woo J, Verduzco-Gutierrez M. Traumatic Brain Injury: An Overview of Epidemiology, Pathophysiology, and Medical Management. Med Clin North Am. 2020;104(2):213-238. doi:10.1016/j.mcna.2019.11.001 [doi]
3. Alba C, Barisano G, Bennett A, Sharma A, Espa PV, Duncan D. Enlarged Perivascular Spaces in Frontal and Temporal Cortical Regions Characterize Seizure Outcome After Traumatic Brain Injury. Proc IEEE Int Symp Biomed Imaging. Published online May 2024. doi:10.1109/isbi56570.2024.10635710 [doi]
4. Hicks AJ, Sinclair B, Shultz SR, et al. Associations of Enlarged Perivascular Spaces With Brain Lesions, Brain Age, and Clinical Outcomes in Chronic Traumatic Brain Injury. Neurology. 2023;101(1):e63-e73. doi:10.1212/WNL.0000000000207370 [doi]
5. Feldman RE, Rutland JW, Fields MC, et al. Quantification of Perivascular Spaces at 7T: A Potential MRI Biomarker for Epilepsy. Seizure. 2018;54:11-18. doi:10.1016/j.seizure.2017.11.004 [doi]
6. Liu C, Habib T, Salimeen M, et al. Quantification of Visible Virchow–Robin Spaces for Detecting the Functional Status of the Glymphatic System in Children With Newly Diagnosed Idiopathic Generalized Epilepsy. Seizure. 2020;78:12-17. doi:10.1016/j.seizure.2020.02.015 [doi]
7. Inglese M, Bomsztyk E, Gonen O, Mannon LJ, Grossman RI, Rusinek H. Dilated Perivascular Spaces: Hallmarks of Mild Traumatic Brain Injury. AJNR Am J Neuroradiol. 2005;26(4):719-724. PMID: 15814911 [pmid]
8. Widjaja E, Zarei Mahmoodabadi S, Go C, et al. Reduced Cortical Thickness in Children With New-Onset Seizures. AJNR Am J Neuroradiol. 2012;33(4):673-677. doi:10.3174/ajnr.A2982 [doi]
9. Boutzoukas EM, Crutcher J, Somoza E, et al. Cortical Thickness in Childhood Left Focal Epilepsy: Thinning Beyond the Seizure Focus. Epilepsy Behav. 2020;102:106825. doi:10.1016/j.yebeh.2019.106825 [doi]
10. Govindarajan KA, Narayana PA, Hasan KM, et al. Cortical Thickness in Mild Traumatic Brain Injury. J Neurotrauma. 2016;33(20):1809-1817. doi:10.1089/neu.2015.4253 [doi]
11. Galovic M, de Tisi J, McEvoy AW, et al. Resective Surgery Prevents Progressive Cortical Thinning in Temporal Lobe Epilepsy. Brain. 2020;143(11):3262-3272. doi:10.1093/brain/awaa284 [doi]
12. Penny WD, Friston KJ, Ashburner JT, Kiebel SJ, Nichols TE. Statistical Parametric Mapping: The Analysis of Functional Brain Images. 1st ed. Elsevier; 2007. doi:10.1016/B978-0-12-372560-8.X5000-1 [doi]
13. Hammers A, Allom R, Koepp MJ, et al. Three-Dimensional Maximum Probability Atlas of the Human Brain, With Particular Reference to the Temporal Lobe. Hum Brain Mapp. 2003;19(4):224-247. doi:https://doi.org/10.1002/hbm.10123 [doi]
14. Desikan RS, Ségonne F, Fischl B, et al. An Automated Labeling System for Subdividing the Human Cerebral Cortex on MRI Scans Into Gyral Based Regions of Interest. NeuroImage. 2006;31(3):968-980. doi:10.1016/j.neuroimage.2006.01.021 [doi]
15. McCarthy P. FSLeyes. Published online September 10, 2019. doi:10.5281/zenodo.3403671 [doi]
16. Smith DA, Verma G, Ranti D, Markowitz M, Balchandani P, Morris L. Perivascular Space Semi-Automatic Segmentation (PVSSAS): A Tool for Segmenting, Viewing and Editing Perivascular Spaces. bioRxiv. Preprint posted online November 17, 2020:2020.11.16.385336. doi:10.1101/2020.11.16.385336 [doi]
17. Gaser C, Dahnke R, Thompson PM, Kurth F, Luders E, The Alzheimer’s Disease Neuroimaging Initiative. CAT: A Computational Anatomy Toolbox for the Analysis of Structural MRI Data. GigaScience. 2024;13:giae049. doi:10.1093/gigascience/giae049 [doi]
18. Kruskal WH, Wallis WA. Use of Ranks in One-Criterion Variance Analysis. J Am Stat Assoc. 1952;47(260):583-621. doi:10.2307/2280779 [doi]
19. Benjamini Y, Hochberg Y. Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J R Stat Soc Ser B Stat Methodol. 1995;57(1):289-300. doi:10.1111/j.2517-6161.1995.tb02031.x [doi]
20. Dunn OJ. Multiple Comparisons Using Rank Sums. Technometrics. 1964;6(3):241-252. doi:10.2307/1266041 [doi]
21. Taing AS, Mundy ME, Ponsford JL, Spitz G. Traumatic Brain Injury Alters the Relationship Between Brain Structure and Episodic Memory. Brain Behav. 2023;13(6):e3012. doi:10.1002/brb3.3012 [doi]
22. Raj A, Mueller SG, Young K, Laxer KD, Weiner M. Network-Level Analysis of Cortical Thickness of the Epileptic Brain. NeuroImage. 2010;52(4):1302-1313. doi:10.1016/j.neuroimage.2010.05.045 [doi]

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http://echo.ismrm.org/p/ISMRM2026/463-04-006