601-02-010 ISMRM Abstract

Water T1 Detects Subtle Muscle Involvement in Becker Muscular Dystrophy Beyond Fat Fraction

Primary: Musculoskeletal - Muscle

Secondary: Contrast Mechanisms - Multi-Contrast

601-02-010 · Muscle MRI in Health and Disease: From Standardization to Application · Thursday, 14 May, 1:40 PM–3:30 PM · Hall 1A

Keywords: Muscle Relaxometry Neuromuscular disease Fat infiltration

Accepted

Sina Graf¹, Valentina Schunk¹, Pierre-Yves Baudin^2,3, Benjamin Marty^2,3, Frank Roemer¹, Arnd Dörfler¹, Michael Uder¹, Elisabetta Gazzerro⁴, Armin M NAGEL^1,5, Teresa Gerhalter ^1,6

¹Uniklinikum Erlangen, Erlangen, Germany

²Association Institut de Myologie, France

³NMR Laboratory, Institute of Myology, Neuromuscular Investigation Center, Paris, France

⁴Charité – Universitätsmedizin Berlin, Berlin, Germany

⁵German Cancer Research Center (DKFZ), Heidelberg, Germany

⁶Medical University of Graz, Graz, Austria

Presenting Author: Teresa Gerhalter

Synopsis

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References

1. Bushby KM, Gardner-Medwin D. The clinical, genetic and dystrophin characteristics of Becker muscular dystrophy: I: natural history. J Neurol. 1993;240(2):98-104. doi:10.1007/BF00858725 [doi]

2. Comi GP, Prelle A, Bresolin N, et al. Clinical variability in Becker muscular dystrophy: genetic, biochemical and immunohistochemical correlates. Brain. 1994;117(pt 1):1-14. doi:10.1093/brain/117.1.1-a [doi]

3. van de Velde NM, Hooijmans MT, Sardjoe Mishre ASD, et al. Selection approach to identify the optimal biomarker using quantitative muscle MRI and functional assessments in Becker muscular dystrophy. Neurology 2021; 97:e513–e522. doi:10.1212/WNL.0000000000012233 [doi]

4. Straub V, Guglieri M. An update on Becker muscular dystrophy. Current Opinion in Neurology 36(5):p 450-454, October 2023. doi:10.1097/WCO.0000000000001191 [doi]

5. Azzabou N, Loureiro de Sousa P, Caldas E, et al. Validation of a generic approach to muscle water T2 determination at 3T in fat-infiltrated skeletal muscle. J MRI 2015: 41(3): 645-653. doi:10.1002/jmri.24613 [doi]

6. Marty B, Reyngoudt H, Boisserie JM, et al. Water-fat separation in MR fingerprinting for quantitative monitoring of the skeletal muscle in neuromuscular disorders. Radiology. 2021; 300: 652-660. doi:10.1148/radiol.2021204028 [doi]

7. Slioussarenko C, Baudin PY, Reyngoudt H, Marty B. Bi-component dictionary matching for MR fingerprinting for efficient quantification of fat fraction and water T1 in skeletal muscle. Magn Reson Med. 2024 Mar;91(3):1179-1189. doi:10.1002/mrm.29901 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/601-02-010