Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
464-01-006 ISMRM Abstract

Perfusion Alters Diffusion MRI Metrics: Disentangling Vascular, CSF, Tissue Contributions across b-Values during Vasodilation

Primary: Diffusion - DWI/DTI/DKI
Secondary: Neuro - Neurofluids
464-01-006 · Diffusion MRI Analysis · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row E
Keywords: Cerebrospinal fluid flow Human brain Hypercapnia Perfusion Diffusion Mismatch Diffusion-weighted imaging (DWI)
Accepted
Yutong Sun 1,2, Nayana Menon2,3, Xiaole Zhong1,2, Jordan Chad2, J. Jean Chen1,2,3
1Department of Medical Biophysics, University of Toronto, Toronto, Canada
2Rotman Research Institute at Baycrest, Toronto, Canada
3Department of Biomedical Engineering, University of Toronto, Toronto, Canada
Presenting Author: Yutong Sun

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References

1. Andersson, J. L., Skare, S., & Ashburner, J. (2003). How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging. Neuroimage, 20(2), 870-888. https://doi.org/10.1016/S1053-8119(03)00336-7 [doi]
2. Chappell, M. A., Groves, A. R., Whitcher, B., & Woolrich, M. W. (2008). Variational Bayesian inference for a nonlinear forward model. IEEE Transactions on Signal Processing, 57(1), 223-236. doi: 10.1109/TSP.2008.2005752 [doi]
3. Ding, A. Y., Chan, K. C., & Wu, E. X. (2012). Effect of cerebrovascular changes on brain DTI quantitation: a hypercapnia study. Magnetic resonance imaging, 30(7), 993-1001.https://doi.org/10.1016/j.mri.2012.02.012 [doi]
4. Le Bihan, D., & Iima, M. (2015). Diffusion magnetic resonance imaging: what water tells us about biological tissues. PLoS biology, 13(7), e1002203. https://doi.org/10.1371/journal.pbio.1002203 [doi]
5. Rudrapatna, U. S., van der Toorn, A., van Meer, M. P., & Dijkhuizen, R. M. (2012). Impact of hemodynamic effects on diffusion-weighted fMRI signals. Neuroimage, 61(1), 106-114.https://doi.org/10.1016/j.neuroimage.2012.02.050 [doi]
6. Sicard, K. M., & Duong, T. Q. (2005). Effects of hypoxia, hyperoxia, and hypercapnia on baseline and stimulus-evoked BOLD, CBF, and CMRO2 in spontaneously breathing animals. Neuroimage, 25(3), 850-858. https://doi.org/10.1016/j.neuroimage.2004.12.010 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/464-01-006