Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
664-02-005 ISMRM Abstract

Age-related brain volumetric changes in a non-human primate model of sporadic cerebral amyloid angiopathy

Primary: Neuro - Alzheimer's Disease
Secondary: Preclinical Animal & in vitro MR - Large Animals, Nonhuman Primates
664-02-005 · Large Animals · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row E
Keywords: Alzheimer's Disease Brain volume Human and non-human primates Cerebral Amyloid Angiopathy Morphometrics
Accepted
Muhammad T Soliman1, Suleiman Khan1, Ema Mir1, Hugo Cuellar1, Charles V Kingsley2, Jody Swain2, Michele M Mulholland3, William D Hopkins3, Thomas Wisniewski1,4,5, Youssef Z Wadghiri6,7, Jelle Veraart8, Henrieta Scholtzova1,9
1Neurology, NYU Grossman School of Medicine, New York, United States of America
2Small Animal Imaging Facility, The University of Texas MD Anderson Cancer Center, Houston, United States of America
3Michale E. Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Houston, United States of America
4Department of Psychiatry, NYU Grossman School of Medicine, New York, United States of America
5Department of Pathology, NYU Grossman School of Medicine, New York, United States of America
6Department of Radiology, NYU Grossman School of Medicine, New York, United States of America
7Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, United States of America
8Department of Radiology, New York University Langone Health, New York, United States of America
9Department of Neurology, NYU Grossman School of Medicine, New York, United States of America
Presenting Author: Mohammed Salman Shazeeb

Synopsis

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References

1. Greenberg SM, Bacskai BJ, Hernandez-Guillamon M, Pruzin J, Sperling R, van Veluw SJ. Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways. Nat Rev Neurol. 2020 Jan;16(1):30-42. doi: 10.1038/s41582-019-0281-2. Epub 2019 Dec 11. PMID: 31827267; PMCID: PMC7268202. [doi] [pmid]
2. Greenberg SM, van Veluw SJ. Cerebral Amyloid Angiopathy. Stroke. 2024 May;55(5):1409-1411. doi: 10.1161/STROKEAHA.124.044293. Epub 2024 Jan 25. PMID: 38269538. [doi] [pmid]
3. Elfenbein HA, Rosen RF, Stephens SL, Switzer RC, Smith Y, Pare J, Mehta PD, Warzok R, Walker LC. Cerebral beta-amyloid angiopathy in aged squirrel monkeys. Histol Histopathol. 2007 Feb;22(2):155-67. doi: 10.14670/HH-22.155. PMID: 17149688. [doi] [pmid]
4. Patel AG, Nehete PN, Krivoshik SR, Pei X, Cho EL, Nehete BP, Ramani MD, Shao Y, Williams LE, Wisniewski T, Scholtzova H. Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer's disease pathology in aged squirrel monkeys. Brain. 2021 Aug 17;144(7):2146-2165. doi: 10.1093/brain/awab129. PMID: 34128045; PMCID: PMC8502485. [doi] [pmid]
5. Nehete PN, Williams LE, Chitta S, Nehete BP, Patel AG, Ramani MD, Wisniewski T, Scholtzova H. Class C CpG Oligodeoxynucleotide Immunomodulatory Response in Aged Squirrel Monkey (Saimiri Boliviensis Boliviensis). Front Aging Neurosci. 2020 Mar 3;12:36. doi: 10.3389/fnagi.2020.00036. PMID: 32194391; PMCID: PMC7063459. [doi] [pmid]
6. Murray, S., Veraart, J., Szabo, J., Akers, C., Genovese, T.S., Goldman, H., Llanos, M., Rusinek, H., Hopkins, W.D., Gray, S.B., Wisniewski, T., Zaim-Wadghiri, Y. and Scholtzova, H. (2023), Development of neuroimaging biomarkers in non-human primate model of sporadic Alzheimer’s disease pathology. Alzheimer's Dement., 19: e079140. https://doi.org/10.1002/alz.079140 [doi]
7. Khan, S., Murray, S., Szabo, J., Soliman, M.T., Goldman, H., Llanos, M., Cho, O., Schissler, E., Kingsley, C., Swain, J., Gray, S.B., Hopkins, W.D., Veraart, J., Wisniewski, T., Zaim-Wadghiri, Y. and Scholtzova, H. (2024), Multi-Parametric MRI assessment of biomarkers in a non-human primate model exhibiting sporadic cerebral amyloid angiopathy. Alzheimer's Dement., 20: e092589. https://doi.org/10.1002/alz.092589 [doi]
8. Avants BB, Yushkevich P, Pluta J, Minkoff D, Korczykowski M, Detre J, Gee JC. The optimal template effect in hippocampus studies of diseased populations. Neuroimage. 2010 Feb 1;49(3):2457-66. doi: 10.1016/j.neuroimage.2009.09.062. Epub 2009 Oct 8. PMID: 19818860; PMCID: PMC2818274. [doi] [pmid]
9. Schilling KG, Gao Y, Christian M, Janve V, Stepniewska I, Landman BA, Anderson AW. A Web-Based Atlas Combining MRI and Histology of the Squirrel Monkey Brain. Neuroinformatics. 2019 Jan;17(1):131-145. doi: 10.1007/s12021-018-9391-z. PMID: 30006920; PMCID: PMC6330248. [doi] [pmid]
10. Schilling KG, Gao Y, Stepniewska I, Wu TL, Wang F, Landman BA, Gore JC, Chen LM, Anderson AW. The VALiDATe29 MRI Based Multi-Channel Atlas of the Squirrel Monkey Brain. Neuroinformatics. 2017 Oct;15(4):321-331. doi: 10.1007/s12021-017-9334-0. PMID: 28748393; PMCID: PMC5671902. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/664-02-005