Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
662-02-003 ISMRM Abstract

Blood Flow Significantly Distorts Measurement Stability and Recovery Kinetics in Single-Voxel Spectroscopy CrCEST

Primary: Contrast Mechanisms - CEST / APT / NOE
Secondary: Contrast Mechanisms - Spectroscopy
662-02-003 · Advances in Chemical Exchange MRI: CEST, APT, and NOE II · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row C
Keywords: CEST & MT Blood vessels Spectroscopy Creatine Muscle Metabolism
Accepted
Ryan Armbruster1, neil wilson1,2,3,4, Ravinder Reddy1,2,3,4,5
1Department of Radiology, University of Pennsylvania, Philadelphia, United States of America
2Center for Advanced Metabolic Imaging in Precision Medicine, Philadelphia, United States of America
3University of Pennsylvania, Philadelphia, United States of America
4Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, United States of America
5Center for Advanced Metabolic Imaging in Precision Medicine, Center for Advanced Metabolic Imaging in Precision Medicine, Philadelphia, United States of America
Presenting Author: Mark A Elliott

Synopsis

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References

1. Bottomley, P. A. Spatial Localization in NMR Spectroscopy in Vivo. Annals of the New York Academy of Sciences 508, 333–348 (1987). DOI: 10.1111/j.1749-6632.1987.tb32915.x PMID: 3326459 [doi] [pmid]
2. Armbruster, R. R. et al. Personalized and muscle-specific OXPHOS measurement with integrated CrCEST MRI and proton MR spectroscopy. Nature Communications 15, 5387 (2024). DOI: 10.1038/s41467-024-49253-6 PMID: 38918361 [doi] [pmid]
3. Kumar, D. et al. Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla. Magnetic Resonance in Medicine 85, 802–817 (2021). DOI: 10.1002/mrm.28463 PMID: 32820572 [doi] [pmid]
4. Kogan, F. et al. Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer. Magnetic Resonance in Medicine 71, 164–172 (2014). DOI: 10.1002/mrm.24641 PMID: 23412909 [doi] [pmid]
5. Liu, G., Gilad, A. A., Bulte, J. W. M., Van Zijl, P. C. M. & McMahon, M. T. High-throughput screening of chemical exchange saturation transfer MR contrast agents. Contrast Media & Molecular Imaging 5, 162–170 (2010). DOI: 10.1002/cmmi.383 PMID: 20586030 [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/662-02-003