Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
607-02-009 ISMRM Abstract

Fluorescent Nanodiamonds MRI Contrast Agents to Protect Endothelial Cells via PI3K/Akt-Mediated Antioxidant Activity

Primary: Contrast Mechanisms - Contrast Agents
Secondary: Preclinical Animal & in vitro MR - Small Animals
607-02-009 · Quantitative and Multi-Contrast MRI: Methods and Applications · Thursday, 14 May, 1:40 PM–3:30 PM · Meeting Room 1.40
Keywords: MRI contrast agent Nanomaterial Oxidative stress Endothelial aging
Accepted
CUNJING ZHENG 1, Wanyufei Liu2, Yanping Lin3, Jinhuan Song4, Jun Peng5, Xuhao Zhu4, zhongbiao xu6, Xiumei Tian7
1Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University,, Guangzhou, China
2Guangzhou zhixin international highschool,Guangzhou 510080, Guangzhou, China
3DongGuan Tungwah Hospital, Dongguan Key Laboratory of Radiology and Molecular Imaging, Dongguan, China
4Department of Radiology, Fuyong People’s Hospital, Shenzhen, China
5Clinical and Technical Support, Philips Healthcare (Guangzhou), Guangzhou, China
6Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, GuangDong, Guangzhou, China
7The School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China
Presenting Author: CUNJING ZHENG

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. de Almeida A J P O, de Almeida Rezende M S, Dantas S H, et al. Unveiling the role of inflammation and oxidative stress on age-related cardiovascular diseases[J]. Oxid Med Cell Longev. 2020, 2020(6):1-20. doi:10.1155/2020/1954398. [doi]
2. Sun H, Zhou Y, Ren J, Qu X. Carbon Nanozymes: Enzymatic Properties, Catalytic Mechanism, and Applications. Angew Chem Int Ed Engl. 2018, 57(30):9224-9237. doi:10.1002/anie.201712469. [doi]
3. Zheng C, Tian X, Cai J, Huang L, Wang S, Yang F, Ma Y, Xie F, Li L. In vivo immunotoxicity of Gd2 O3 :Eu3+ nanoparticles and the associated molecular mechanism. J Biochem Mol Toxicol. 2020 Nov;34(11):e22562. doi: 10.1002/jbt.22562. Epub 2020 Jul 13. PMID: 32659858. [doi] [pmid]
4. Wu G, Li S, Qu G, et al. Genistein alleviates H2O2-induced senescence of human umbilical vein endothelial cells via regulating the TXNIP/NLRP3 axis. Pharm Biol. 2021, 59(1):1388-1401. doi:10.1080/13880209.2021.1979052. [doi]
5. Duranova H, Kuzelova L, Borotova P, Simora V, Fialkova V. Human Umbilical Vein Endothelial Cells as a Versatile Cellular Model System in Diverse Experimental Paradigms: An Ultrastructural Perspective. Microsc Microanal. 2024, 30(3):419-439. doi:10.1093/mam/ozae048. [doi]
6. Jiang B, Duan D, Gao L, et al. Standardized assays for determining the catalytic activity and kinetics of peroxidase-like nanozymes[J]. Nature Protocols: Recipes for Researchers, 2018, 13(7):1506-1520. doi:10.1038/s41596-018-0001-1. [doi]
7. Lai WF, Wong WT. Roles of the actin cytoskeleton in aging and age-associated diseases. Ageing Res Rev. 2020 Mar;58:101021. doi: 10.1016/j.arr.2020.101021. Epub 2020 Jan 20. PMID: 31968269. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/607-02-009