501-04-009 ISMRM Abstract

The Role of Water-Specific T1 Mapping in Reflecting Hepatic Tissue Composition: Comparison with MRE, PDFF, and R2*

Primary: Body - Liver

Secondary: Contrast Mechanisms - Relaxometry

501-04-009 · Applications of Quantitative MRI in the Body · Wednesday, 13 May, 4:00 PM–5:50 PM · Hall 1A

Keywords: Liver Fibrosis Liver T1 Fatty liver disease Magnetic Resonance Elastography (MRE) Water-fat separation

Accepted

Jingjia Chen ^1,2, Mahesh B Keerthivasan³, Ute Goerke⁴, Justin Quimbo^1,2, Meng Yin⁵, Krishna Shanbhogue^1,2, Hersh Chandarana^1,2, Li Feng^1,2

¹Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, United States of America

²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, United States of America

³Siemens Medical Solutions, Boston, United States of America

⁴Siemens Medical Solutions, Tucson, United States of America

⁵Department of Radiology, Mayo Clinic, Rochester, United States of America

Presenting Author: Jingjia Chen

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References

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2. Hoad CL, Palaniyappan N, Kaye P, et al. A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histological factors. NMR in Biomedicine. 2015;28(6):706-714. doi:10.1002/nbm.3299 [doi]

3. Hernando D, Kellman P, Haldar JP, Liang ZP. Robust Water/Fat Separation in the Presence of Large Field Inhomogeneities Using a Graph Cut Algorithm. Magn Reson Med. 2010;63(1):79-90. doi:10.1002/mrm.22177 [doi]

4. Chen J, Huang Y, Xia D, Chandarana H, Feng L. 3D Fat/water-separated liver T1 mapping: a study on the influence of fat and repeatability. In: Proceedings of the 2024 Annual Meeting of ISMRM. 0428. Wiley; 2024.

5. Mozes FE, Tunnicliffe EM, Pavlides M, Robson MD. Influence of fat on liver T1 measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T. Journal of Magnetic Resonance Imaging. 2016;44(1):105-111. doi:10.1002/jmri.25146 [doi]

6. Klaus JB, Goerke U, Klarhöfer M, et al. MRI Dixon Fat-Corrected Look-Locker T1 Mapping for Quantification of Liver Fibrosis and Inflammation—A Comparison With the Non–Fat-Corrected Shortened Modified Look-Locker Inversion Recovery Technique. Investigative Radiology. 2024;59(11):754. doi:10.1097/RLI.0000000000001084 [doi]

7. Feng L, Liu F, Soultanidis G, et al. Magnetization-prepared GRASP MRI for rapid 3D T1 mapping and fat/water-separated T1 mapping. Magn Reson Med. 2021;86(1):97-114. doi:10.1002/mrm.28679 [doi]

8. Li Z, Xu X, Yang Y, Feng L. Repeatability and robustness of MP-GRASP T1 mapping. Magnetic Resonance in Medicine. 2022;87(5):2271-2286. doi:10.1002/mrm.29131 [doi]

9. Deichmann R, Haase A. Quantification of T1 values by SNAPSHOT-FLASH NMR imaging. Journal of Magnetic Resonance (1969). 1992;96(3):608-612. doi:10.1016/0022-2364(92)90347-A [doi]

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http://echo.ismrm.org/p/ISMRM2026/501-04-009