2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
501-04-009 ISMRM Abstract

The Role of Water-Specific T1 Mapping in Reflecting Hepatic Tissue Composition: Comparison with MRE, PDFF, and R2*

Primary: Body - Liver
Secondary: Contrast Mechanisms - Relaxometry
501-04-009 · Applications of Quantitative MRI in the Body · Wednesday, 13 May, 4:00 PM–5:50 PM · Hall 1A
Keywords: Liver Fibrosis Liver T1 Fatty liver disease Magnetic Resonance Elastography (MRE) Water-fat separation
Accepted
Jingjia Chen 1,2, Mahesh Keerthivasan3, Ute Goerke3, Justin Quimbo1,2, Meng Yin4, Krishna Shanbhogue1,2, Hersh Chandarana1,2, Li Feng1,2
1Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University, New York, United States of America
2Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University, New York, United States of America
3Siemens Healthcare (United States), Malvern, United States of America
4Department of Radiology, Mayo Clinic, Rochester, United States of America
Presenting Author: Jingjia Chen

Synopsis

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Preview figure: The Role of Water-Specific T1 Mapping in Reflecting Hepatic Tissue Composition: Comparison with MRE, PDFF, and R2*
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References

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2. Hoad CL, Palaniyappan N, Kaye P, et al. A study of T1 relaxation time as a measure of liver fibrosis and the influence of confounding histological factors. NMR in Biomedicine. 2015;28(6):706-714. doi:10.1002/nbm.3299 [doi]
3. Hernando D, Kellman P, Haldar JP, Liang ZP. Robust Water/Fat Separation in the Presence of Large Field Inhomogeneities Using a Graph Cut Algorithm. Magn Reson Med. 2010;63(1):79-90. doi:10.1002/mrm.22177 [doi]
4. Chen J, Huang Y, Xia D, Chandarana H, Feng L. 3D Fat/water-separated liver T1 mapping: a study on the influence of fat and repeatability. In: Proceedings of the 2024 Annual Meeting of ISMRM. 0428. Wiley; 2024.
5. Mozes FE, Tunnicliffe EM, Pavlides M, Robson MD. Influence of fat on liver T1 measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T. Journal of Magnetic Resonance Imaging. 2016;44(1):105-111. doi:10.1002/jmri.25146 [doi]
6. Klaus JB, Goerke U, Klarhöfer M, et al. MRI Dixon Fat-Corrected Look-Locker T1 Mapping for Quantification of Liver Fibrosis and Inflammation—A Comparison With the Non–Fat-Corrected Shortened Modified Look-Locker Inversion Recovery Technique. Investigative Radiology. 2024;59(11):754. doi:10.1097/RLI.0000000000001084 [doi]
7. Feng L, Liu F, Soultanidis G, et al. Magnetization-prepared GRASP MRI for rapid 3D T1 mapping and fat/water-separated T1 mapping. Magn Reson Med. 2021;86(1):97-114. doi:10.1002/mrm.28679 [doi]
8. Li Z, Xu X, Yang Y, Feng L. Repeatability and robustness of MP-GRASP T1 mapping. Magnetic Resonance in Medicine. 2022;87(5):2271-2286. doi:10.1002/mrm.29131 [doi]
9. Deichmann R, Haase A. Quantification of T1 values by SNAPSHOT-FLASH NMR imaging. Journal of Magnetic Resonance (1969). 1992;96(3):608-612. doi:10.1016/0022-2364(92)90347-A [doi]

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http://echo.ismrm.org/p/ISMRM2026/501-04-009